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Gene Review:

Rn18s - 18S ribosomal RNA

Mus musculus

Kominami, R. et al., Oberbäumer, I., Hampe, A. et al., Levey, I.L. et al., Donev, R.M. et al., et al.

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Disease relevance of Rn18s

Analysis of genomic DNA from several murine cell lines revealed that PYS cells contain at least one copy of 18S RNA with the B2 element which is not present in the genome of other murine cell lines derived from the same teratocarcinoma [1].
Both 28S and 18S RNA are conserved during the initial stages of compensatory renal hypertrophy to an extent sufficient to account for the rest of the observed accumulation of rRNA [2].

High impact information on Rn18s

At least three kinds of repetitive sequences are present in the non-transcribed spacer region; two of them are located 13 kb upstream from the 5'-end of 18S RNA gene and the other located 1 to 4 kb downstream from the 3'-end of 28S RNA gene [3].
Comparison of the terminal regional of 5.8S RNA with those of 18S RNA reveals differences which imply a more complex mechanism underlying the maturation of 45S precursor RNA than the finding of identical structure would have suggested [4].
Scaffold RNA represented three fractions: a major RNA fraction with an electrophoretic mobility corresponding to that of 5S RNA and two minor fractions with electrophoretic mobilities somewhat lower than that of 18S RNA [5].
Electrophoretic analyses revealed that preincubation of blastocysts in 100 microgram/ml alpha-amanitin reduced labelling of cytoplasmic 28S and 18S RNA by inhibition of both synthesis and maturation of nucleolar 45SrRNA-precursor [6].
The low-P(i) diet also elicited an increase in the abundance of NaPi-2 mRNA, relative to the 18S RNA, in normal (157 +/- 9% of control diet, P < 0.05) and Hyp mice (194 +/- 10% of control diet, P < 0.01) [7].

References

Retroposons do jump: a B2 element recently integrated in an 18S rDNA gene. Oberbäumer, I. Nucleic Acids Res. (1992) [Pubmed]
Conservation of ribosomal RNA during compensatory renal hypertrophy. A major mechanism in RNA accretion. Melvin, W.T., Kumar, A., Malt, R.A. J. Cell Biol. (1976) [Pubmed]
Organization of ribosomal RNA gene repeats of the mouse. Kominami, R., Urano, Y., Mishima, Y., Muramatsu, M. Nucleic Acids Res. (1981) [Pubmed]
Nucleotide sequence study of mouse 5.8S ribosomal RNA. Hampe, A., Eladari, M.E., Galibert, F. Biochimie (1976) [Pubmed]
Macromolecular and ultrastructural organization of the mitotic chromosome scaffold. Donev, R.M., Djondjurov, L.P. DNA Cell Biol. (1999) [Pubmed]
Effects of alpha-amanitin on RNA synthesis by mouse embryos in culture. Levey, I.L., Brinster, R.L. J. Exp. Zool. (1978) [Pubmed]
Effect of P(i) restriction on renal Na(+)-P(i) cotransporter mRNA and immunoreactive protein in X-linked Hyp mice. Tenenhouse, H.S., Martel, J., Biber, J., Murer, H. Am. J. Physiol. (1995) [Pubmed]

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