High impact information on ELA1

• The two activities of PDX1 are exhibited through the 10-bp B element of the transcriptional enhancer of the pancreatic elastase I gene (ELA1) [1].
• In pancreatic acinar cells the activity of the B element requires other elements of the ELA1 enhancer; in beta-cells the B element can activate a promoter in the absence of other enhancer elements [1].
• PBX1b.MEIS2b complex cooperates with the PTF1 basic helix-loop-helix complex to activate an ELA1 minienhancer in HeLa cells and that this cooperation requires all three homeoprotein subunits, including the PDX1 activation domain [2].
• ELA1 was previously mapped to chromosome 12 using a panel of mouse-human somatic cell hybrids [3].
• We now report the physical and cytogenetic localization of the ELA1 gene [3].

Biological context of ELA1

• Physical mapping of the human ELA1 gene between D12S361 and D12S347 on chromosome 12q13 [3].
• ELA1, the pancreatic elastase 1 gene, is conserved in mammalian genomes [3].
• TRY1 was assigned to human chromosome 7q22----qter, CTRB to chromosome 16, and ELA1 to chromosome 12 [4].

Anatomical context of ELA1

• BACKGROUND: The archetypal mammalian elastase (ELA1) is not expressed in the human pancreas, because evolutionary mutations suppressed transcription of the ELA1 gene [5].

Analytical, diagnostic and therapeutic context of ELA1

• Using fluorescence in situ hybridization, we determined that ELA1 maps to 12q13 [3].

References