The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Rps19  -  ribosomal protein S19

Mus musculus

Synonyms: 40S ribosomal protein S19, Dsk3
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Rps19


High impact information on Rps19

  • We produced C57BL/6J mice with a targeted disruption of murine Rps19 to study its role in erythropoiesis and development [2].
  • Our findings indicate that zygotes which are Rps19(-/-) do not form blastocysts, whereas one normal Rps19 allele in C57BL/6J mice is sufficient to maintain normal ribosomal and possibly extraribosomal functions [2].
  • In contrast, mice heterozygous for the disrupted Rps19 allele have normal growth and organ development, including that of the hematopoietic system [2].
  • The gene encoding ribosomal protein S19 (RPS19) is mutated in approximately 25% of patients with Diamond-Blackfan anemia (DBA), which is a rare congenital erythroblastopenia [3].
  • To investigate a possible role for RPS19 in erythropoiesis, we looked for proteins associated with mouse RPS19 using a yeast two-hybrid system and identified a novel protein, which we named S19 binding protein (S19BP) [3].

Anatomical context of Rps19

  • Mice homozygous for the disrupted Rps19 were not identified as early as the blastocyst stage, indicating a lethal effect [2].

Other interactions of Rps19

  • We estimated the Rps19 levels in hematopoietic tissues and we analyzed erythrocyte deaminase activity and globin isoforms which are used as markers for DBA [1].


  1. Erythropoiesis in the Rps19 disrupted mouse: Analysis of erythropoietin response and biochemical markers for Diamond-Blackfan anemia. Matsson, H., Davey, E.J., Fröjmark, A.S., Miyake, K., Utsugisawa, T., Flygare, J., Zahou, E., Byman, I., Landin, B., Ronquist, G., Karlsson, S., Dahl, N. Blood Cells Mol. Dis. (2006) [Pubmed]
  2. Targeted disruption of the ribosomal protein S19 gene is lethal prior to implantation. Matsson, H., Davey, E.J., Draptchinskaia, N., Hamaguchi, I., Ooka, A., Levéen, P., Forsberg, E., Karlsson, S., Dahl, N. Mol. Cell. Biol. (2004) [Pubmed]
  3. A novel nucleolar protein interacts with ribosomal protein S19. Maeda, N., Toku, S., Kenmochi, N., Tanaka, T. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
WikiGenes - Universities