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MeSH Review

Hematopoietic System

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Disease relevance of Hematopoietic System


High impact information on Hematopoietic System


Biological context of Hematopoietic System


Anatomical context of Hematopoietic System

  • Lsc is expressed primarily in the hematopoietic system and links the activation of G alpha(12) and G alpha(13)-coupled receptors to actin polymerization in B and T cells [16].
  • Many of the properties of human T200 homologue are similar to those of murine T200 glycoprotein: it is broadly distributed within the hematopoietic system but is not detectable on nonhematopoietic cells; there are also structural differences between the forms of the glycoprotein found on T and B lymphoblastoid cell lines [17].
  • Lactoferrin (Lf), the major iron-binding component of milk, also a major constituent of the specific granules of neutrophils involved in antimicrobial activity and a glycoprotein thought to play a role in regulatory functions in the hematopoietic system as well as other physiologic activities, is shown to occur in three isoforms [18].
  • The phylogenetic distribution of PDGF homologue does not correlate with platelet distribution since platelets and their precursor cell--the bone marrow megacaryocyte--are unique to the mammalian hematopoietic system [19].
  • The bZip transcription factor MafB is expressed specifically in the myeloid lineage of the hematopoietic system and is up-regulated successively during myeloid differentiation from multipotent progenitors to macrophages [20].

Associations of Hematopoietic System with chemical compounds


Gene context of Hematopoietic System

  • In contrast, mice heterozygous for the disrupted Rps19 allele have normal growth and organ development, including that of the hematopoietic system [26].
  • SHP-1 is an SH2-containing cytoplasmic tyrosine phosphatase that is widely distributed in cells of the hematopoietic system [27].
  • In addition, one mouse gene in the Ifi-200 gene family and the human MNDA and IFI 16 genes show expression and/or regulation restricted to cells of the hematopoietic system, suggesting that these genes participate in blood cell-specific responses to interferons [28].
  • Within the hematopoietic system, the effects of IL-11 are largely manifest only through combination with other cytokines, including IL-3 and Steel factor (SF) [29].
  • These findings place Hand at a nexus of the transcriptional networks that govern cardiogenesis and hematopoiesis, and indicate that the transcriptional pathways involved in development of the cardiovascular, excretory and hematopoietic systems may be more closely related than previously appreciated [30].

Analytical, diagnostic and therapeutic context of Hematopoietic System


  1. 5-Fluorouracil, 1,3-bis(2-chloroethyl)-1-nitrosourea, and 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea: effect on the human granulopoietic system. Lohrmann, H.P., Lepp, K.A., Schreml, W. J. Natl. Cancer Inst. (1982) [Pubmed]
  2. Inhibition of proliferation by c-myb antisense RNA and oligodeoxynucleotides in transformed neuroectodermal cell lines. Raschellà, G., Negroni, A., Skorski, T., Pucci, S., Nieborowska-Skorska, M., Romeo, A., Calabretta, B. Cancer Res. (1992) [Pubmed]
  3. Pearson marrow-pancreas syndrome with worsening cardiac function caused by pleiotropic rearrangement of mitochondrial DNA. Krauch, G., Wilichowski, E., Schmidt, K.G., Mayatepek, E. Am. J. Med. Genet. (2002) [Pubmed]
  4. Postnatal effects of chemically induced intrauterine growth retardation on some hematological values in the rat. Amortegui, A.J., Feinberg, S.S., Figallo, E.M. Biol. Neonate (1976) [Pubmed]
  5. Toxicity, pathological effects, and antineoplastic activity of a non-toxic dose of 5-fluorouracil in combination with methotrexate. Robbins, T.J., Bowen, D. Anticancer Res. (1988) [Pubmed]
  6. An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis. Tokuhiro, S., Yamada, R., Chang, X., Suzuki, A., Kochi, Y., Sawada, T., Suzuki, M., Nagasaki, M., Ohtsuki, M., Ono, M., Furukawa, H., Nagashima, M., Yoshino, S., Mabuchi, A., Sekine, A., Saito, S., Takahashi, A., Tsunoda, T., Nakamura, Y., Yamamoto, K. Nat. Genet. (2003) [Pubmed]
  7. Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family. Weih, F., Carrasco, D., Durham, S.K., Barton, D.S., Rizzo, C.A., Ryseck, R.P., Lira, S.A., Bravo, R. Cell (1995) [Pubmed]
  8. Requirement of the RNA editing deaminase ADAR1 gene for embryonic erythropoiesis. Wang, Q., Khillan, J., Gadue, P., Nishikura, K. Science (2000) [Pubmed]
  9. Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Cozzio, A., Passegué, E., Ayton, P.M., Karsunky, H., Cleary, M.L., Weissman, I.L. Genes Dev. (2003) [Pubmed]
  10. Novel murine homeo box gene on chromosome 1 expressed in specific hematopoietic lineages and during embryogenesis. Allen, J.D., Lints, T., Jenkins, N.A., Copeland, N.G., Strasser, A., Harvey, R.P., Adams, J.M. Genes Dev. (1991) [Pubmed]
  11. Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response. Brakebusch, C., Fillatreau, S., Potocnik, A.J., Bungartz, G., Wilhelm, P., Svensson, M., Kearney, P., Körner, H., Gray, D., Fässler, R. Immunity (2002) [Pubmed]
  12. Involvement of peripheral benzodiazepine receptors in the protection of hematopoietic cells against oxygen radical damage. Carayon, P., Portier, M., Dussossoy, D., Bord, A., Petitprêtre, G., Canat, X., Le Fur, G., Casellas, P. Blood (1996) [Pubmed]
  13. Interferon alpha induces rapid tyrosine phosphorylation of the vav proto-oncogene product in hematopoietic cells. Platanias, L.C., Sweet, M.E. J. Biol. Chem. (1994) [Pubmed]
  14. Tie receptors and their angiopoietin ligands are context-dependent regulators of vascular remodeling. Eklund, L., Olsen, B.R. Exp. Cell Res. (2006) [Pubmed]
  15. Retroviral transfer of the human MDR1 gene confers resistance to bisantrene-specific hematotoxicity. Aksentijevich, I., Cardarelli, C.O., Pastan, I., Gottesman, M.M. Clin. Cancer Res. (1996) [Pubmed]
  16. Lsc is required for marginal zone B cells, regulation of lymphocyte motility and immune responses. Girkontaite, I., Missy, K., Sakk, V., Harenberg, A., Tedford, K., Pötzel, T., Pfeffer, K., Fischer, K.D. Nat. Immunol. (2001) [Pubmed]
  17. Human homologue of murine T200 glycoprotein. Omary, M.B., Trowbridge, I.S., Battifora, H.A. J. Exp. Med. (1980) [Pubmed]
  18. Multiple molecular forms of human lactoferrin. Identification of a class of lactoferrins that possess ribonuclease activity and lack iron-binding capacity. Furmanski, P., Li, Z.P., Fortuna, M.B., Swamy, C.V., Das, M.R. J. Exp. Med. (1989) [Pubmed]
  19. Phylogenetic analysis of platelet-derived growth factor by radio-receptor assay. Singh, J.P., Chaikin, M.A., Stiles, C.D. J. Cell Biol. (1982) [Pubmed]
  20. MafB is an inducer of monocytic differentiation. Kelly, L.M., Englmeier, U., Lafon, I., Sieweke, M.H., Graf, T. EMBO J. (2000) [Pubmed]
  21. Prophylactic pretreatment of mice with hematopoietic growth factors induces expansion of primitive cell compartments and results in protection against 5-fluorouracil-induced toxicity. de Haan, G., Donte, B., Engel, C., Loeffler, M., Nijhof, W. Blood (1996) [Pubmed]
  22. Selective role of a distinct tyrosine residue on Tie2 in heart development and early hematopoiesis. Tachibana, K., Jones, N., Dumont, D.J., Puri, M.C., Bernstein, A. Mol. Cell. Biol. (2005) [Pubmed]
  23. Enhanced repopulation of murine hematopoietic organs in sublethally irradiated mice after treatment with ciprofloxacin. Kletter, Y., Riklis, I., Shalit, I., Fabian, I. Blood (1991) [Pubmed]
  24. Lack of alpha4 integrin expression in stem cells restricts competitive function and self-renewal activity. Priestley, G.V., Scott, L.M., Ulyanova, T., Papayannopoulou, T. Blood (2006) [Pubmed]
  25. Intestinal tumors in mice treated with a single injection of N-nitroso-N-butylurea. Ward, J.M., Weisburger, E.K. Cancer Res. (1975) [Pubmed]
  26. Targeted disruption of the ribosomal protein S19 gene is lethal prior to implantation. Matsson, H., Davey, E.J., Draptchinskaia, N., Hamaguchi, I., Ooka, A., Levéen, P., Forsberg, E., Karlsson, S., Dahl, N. Mol. Cell. Biol. (2004) [Pubmed]
  27. Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1. Jiao, H., Berrada, K., Yang, W., Tabrizi, M., Platanias, L.C., Yi, T. Mol. Cell. Biol. (1996) [Pubmed]
  28. The human myeloid cell nuclear differentiation antigen gene is one of at least two related interferon-inducible genes located on chromosome 1q that are expressed specifically in hematopoietic cells. Briggs, R.C., Briggs, J.A., Ozer, J., Sealy, L., Dworkin, L.L., Kingsmore, S.F., Seldin, M.F., Kaur, G.P., Athwal, R.S., Dessypris, E.N. Blood (1994) [Pubmed]
  29. Effects of interleukin-11 on the proliferation and cell cycle status of myeloid leukemic cells. Hu, J.P., Cesano, A., Santoli, D., Clark, S.C., Hoang, T. Blood (1993) [Pubmed]
  30. Hand is a direct target of Tinman and GATA factors during Drosophila cardiogenesis and hematopoiesis. Han, Z., Olson, E.N. Development (2005) [Pubmed]
  31. Interleukin 6 perfusion stimulates reconstitution of the immune and hematopoietic systems after 5-fluorouracil treatment. Takatsuki, F., Okano, A., Suzuki, C., Miyasaka, Y., Hirano, T., Kishimoto, T., Ejima, D., Akiyama, Y. Cancer Res. (1990) [Pubmed]
  32. Expression of AML1-ETO fusion transcripts and detection of minimal residual disease in t(8;21)-positive acute myeloid leukemia. Chang, K.S., Fan, Y.H., Stass, S.A., Estey, E.H., Wang, G., Trujillo, J.M., Erickson, P., Drabkin, H. Oncogene (1993) [Pubmed]
  33. The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3. García-Cuéllar, M.P., Zilles, O., Schreiner, S.A., Birke, M., Winkler, T.H., Slany, R.K. Oncogene (2001) [Pubmed]
  34. Fog1 is required for cardiac looping in zebrafish. Walton, R.Z., Bruce, A.E., Olivey, H.E., Najib, K., Johnson, V., Earley, J.U., Ho, R.K., Svensson, E.C. Dev. Biol. (2006) [Pubmed]
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