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Gene Review:

ARHGAP27 - Rho GTPase activating protein 27

Homo sapiens

Synonyms: CAMGAP1, CIN85-associated multi-domain-containing Rho GTPase-activating protein 1, FLJ43547, PP905, Rho GTPase-activating protein 27, ...

Katoh, Y. et al., Sakakibara, T. et al.

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Disease relevance of ARHGAP27

ARHGAP27 mRNA was expressed in germinal center B cell, spleen, chronic lymphocytic leukemia, pancreatic cancer, and lung cancer [1].

High impact information on ARHGAP27

Overexpression of a truncated form of CAMGAP1 interferes with the internalization of transferrin receptors, suggesting that CAMGAP1 may play a role in clathrin-mediated endocytosis [2].
Protein binding and expression studies indicated that the second SH3 domain of CIN85 binds to a proline-rich region of CAMGAP1 [2].
ARHGAP27 gene was located at human chromosome 17q21, while ARHGAP12 gene was located at human chromosome 10p11 [1].
Here, we characterized human ARHGAP27 gene by using bioinformatics [1].
ARHGAP27 isoform 1 consists of exons 1-17, while ARHGAP27 isoform 2 consists of exons 1B, and 2-17 [1].

Biological context of ARHGAP27

ARHGAP27 gene encoded two isoforms due to alternative splicing of alternative promoter type [1].

References

Identification and characterization of ARHGAP27 gene in silico. Katoh, Y., Katoh, M. Int. J. Mol. Med. (2004) [Pubmed]
Identification and characterization of a novel Rho GTPase activating protein implicated in receptor-mediated endocytosis. Sakakibara, T., Nemoto, Y., Nukiwa, T., Takeshima, H. FEBS Lett. (2004) [Pubmed]

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arhgap27	Danio rerio
arhgap27l	Danio rerio
ARHGAP27	Gallus gallus
Arhgap27	Mus musculus
ARHGAP27	Pan troglodytes
Arhgap27	Rattus norvegicus
arhgap27	Xenopus (Silurana) tropicalis

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