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Gene Review

Sec23a  -  SEC23A (S. cerevisiae)

Mus musculus

Synonyms: Msec23, Protein transport protein Sec23A, SEC23-related protein A, Sec23, Sec23r
 
 
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Disease relevance of Sec23a

  • We find that activated Sar1 in combination with either Sec23 or the Sec23-24 complex is necessary and sufficient to recover with high efficiency the type 1 transmembrane cargo protein vesicular stomatitis virus glycoprotein in a detergent-soluble prebudding protein complex that excludes ER resident proteins [1].
 

High impact information on Sec23a

  • To define possible protein interactions between cargo and coat components, we recruited either glutathione-S-transferase (GST)-tagged Sar1 or GST- Sec23 to ER microsomes [1].
  • Although the Sec23-24 complex or the monomeric Sec23 subunit were found to be the minimal cytosolic components recruited to membranes after the activation of Sar1, the addition of the mammalian Sec13-31 complex is required to complete budding [1].
  • We have isolated a yeast SEC23-related clone (Msec23) from mouse fibroblast cDNA library [2].
 

Anatomical context of Sec23a

  • Further, Msec23 is differentially expressed in mouse tissues with its high level in brain and fibroblasts [2].

References

  1. Cargo selection by the COPII budding machinery during export from the ER. Aridor, M., Weissman, J., Bannykh, S., Nuoffer, C., Balch, W.E. J. Cell Biol. (1998) [Pubmed]
  2. Identification and differential expression of yeast SEC23-related gene (Msec23) in mouse tissues. Wadhwa, R., Kaul, S.C., Komatsu, Y., Ikawa, Y., Sarai, A., Sugimoto, Y. FEBS Lett. (1993) [Pubmed]
 
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