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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CDY2B  -  chromodomain protein, Y-linked, 2B

Homo sapiens

Synonyms: CDY
 
 
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High impact information on CDY2B

  • Here, we characterize the CDY-related mammalian gene family, focusing on three aspects of its evolution: gene copy number, tissue expression profile and amino acid sequence [1].
  • However, in consideration of the high levels of identity between CDY1 and CDY2 (98% at the protein level), the delayed up-regulation of CDY1 transcripts could be attributable to temporal changes in dosage requirements [2].
  • It is suggested that CDY2 is apparently required in the early stages of spermatogenesis, whereas CDY1 transcripts are required later on in the process [2].
  • CDY2 was expressed whenever germ cells were present, but CDY1 major and especially CDY1 minor and short transcripts were identified almost exclusively when mature spermatids/spermatozoa were detected [2].

References

  1. The CDY-related gene family: coordinated evolution in copy number, expression profile and protein sequence. Dorus, S., Gilbert, S.L., Forster, M.L., Barndt, R.J., Lahn, B.T. Hum. Mol. Genet. (2003) [Pubmed]
  2. Members of the CDY family have different expression patterns: CDY1 transcripts have the best correlation with complete spermatogenesis. Kleiman, S.E., Yogev, L., Hauser, R., Botchan, A., Bar-Shira Maymon, B., Schreiber, L., Paz, G., Yavetz, H. Hum. Genet. (2003) [Pubmed]
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