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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Table of contents

About

Terms

 

Gene Review: 

CDY2A  -  chromodomain protein, Y-linked, 2A

Homo sapiens

Synonyms: CDY, CDY2
 
 
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Disease relevance of CDY2A

 

High impact information on CDY2A

  • CDY genes retain CDYL exonic sequences but lack its introns [2].
  • Here, we characterize the CDY-related mammalian gene family, focusing on three aspects of its evolution: gene copy number, tissue expression profile and amino acid sequence [3].
  • We detected 485 duplicated chromosomal segments in the human genome containing CDY orthologs, 331 of which are found duplicated in the mouse genome and within regions syntenic between human and mouse, indicating that these were generated earlier than the human-mouse split [4].
  • It can be concluded that the non-recombining part of the Y-chromosomes including CDY and DAZ, was exposed to species-specific amplifications, diversifications and rearrangements [5].

References

  1. Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis. Lahn, B.T., Tang, Z.L., Zhou, J., Barndt, R.J., Parvinen, M., Allis, C.D., Page, D.C. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome. Lahn, B.T., Page, D.C. Nat. Genet. (1999) [Pubmed]
  3. The CDY-related gene family: coordinated evolution in copy number, expression profile and protein sequence. Dorus, S., Gilbert, S.L., Forster, M.L., Barndt, R.J., Lahn, B.T. Hum. Mol. Genet. (2003) [Pubmed]
  4. New evidence for genome-wide duplications at the origin of vertebrates using an amphioxus gene set and completed animal genomes. Panopoulou, G., Hennig, S., Groth, D., Krause, A., Poustka, A.J., Herwig, R., Vingron, M., Lehrach, H. Genome Res. (2003) [Pubmed]
  5. Comparative mapping of CDY and DAZ in higher primates. Wimmer, R., Kühl, H., Röttger, S., Schempp, W. Cytogenet. Genome Res. (2002) [Pubmed]
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