Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Sepw1 - selenoprotein W, muscle 1

Mus musculus

Synonyms: SelW, Selenoprotein W, Selw

Loflin, J. et al., Wimmer, U. et al.

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High impact information on Sepw1

Selenoprotein W during development and oxidative stress [1].
Selenoprotein W exhibited an immediate response to oxidative stress in proliferating myoblasts, after exposure to hydrogen peroxide, similar to gluteraldehyde-3-phosphate dehydrogenase [1].
Selenoprotein W was highly expressed in proliferating myoblasts and less or not in differentiated myotubes [1].
Selenoprotein W, a member of the selenoprotein family was expressed in developing nervous system, skeletal muscles and heart in mice [1].
MTF-1 is required for the basal expression of selenoprotein W, muscle 1 gene (Sepw1) that encodes a glutathione-binding and putative antioxidant protein, supporting a role of MTF-1 in the oxidative stress response [2].

References

Selenoprotein W during development and oxidative stress. Loflin, J., Lopez, N., Whanger, P.D., Kioussi, C. J. Inorg. Biochem. (2006) [Pubmed]
Two major branches of anti-cadmium defense in the mouse: MTF-1/metallothioneins and glutathione. Wimmer, U., Wang, Y., Georgiev, O., Schaffner, W. Nucleic Acids Res. (2005) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

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