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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Serf1  -  small EDRK-rich factor 1

Mus musculus

Synonyms: 4F5, Msmac1, Protein 4F5, Small EDRK-rich factor 1, m4F5
 
 
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High impact information on Serf1

  • A monoclonal antibody (4F5) was generated against a portion of the putative extracellular domain of glutamate receptor subunit GluR5 [1].
  • Western blot analyses and immunocytochemistry of transfected human embryonic kidney 293 cells confirmed that monoclonal antibody 4F5 was specific for GluR5, -6, and -7 (the three identified members of the kainate receptor subunit class), but did not recognize GluR1, -2, or -3 (the AMPA/kainate receptor subunit class) [1].
  • Structural analysis indicated that the structure of 4F5 is that of a standard Fab and its combining site is flat and is rich in tyrosine residues [2].
  • Deduced amino acid sequence and amino acid sequence obtained from diffraction analysis were compared and used to finalize the 4F5 Fab model [2].

References

  1. Selective distribution of kainate receptor subunit immunoreactivity in monkey neocortex revealed by a monoclonal antibody that recognizes glutamate receptor subunits GluR5/6/7. Huntley, G.W., Rogers, S.W., Moran, T., Janssen, W., Archin, N., Vickers, J.C., Cauley, K., Heinemann, S.F., Morrison, J.H. J. Neurosci. (1993) [Pubmed]
  2. X-ray crystal structure of a monoclonal antibody that binds to a major autoantigenic epitope on thyroid peroxidase. Hendry, E., Taylor, G., Grennan-Jones, F., Sullivan, A., Liddy, N., Godfrey, J., Hayakawa, N., Powell, M., Sanders, J., Furmaniak, J., Smith, B.R. Thyroid (2001) [Pubmed]
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