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Gene Review

SERF1A  -  small EDRK-rich factor 1A (telomeric)

Homo sapiens

Synonyms: 4F5, FAM2A, H4F5, SERF1, SMAM1
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Disease relevance of SERF1A


High impact information on SERF1A

  • Using comparative genomics to screen for such a factor among evolutionarily conserved sequences between mouse and human, we have identified a novel transcript, H4F5, which lies closer to SMN1 than any previously identified gene in the region [4].
  • A multi-copy microsatellite marker that is deleted in more than 90% of type I SMA chromosomes is embedded in an intron of this gene, indicating that H4F5 is also highly deleted in type I SMA chromosomes, and thus is a candidate phenotypic modifier for SMA [4].
  • We previously reported that chickens infected with the avian adenovirus SMAM-1 developed a unique syndrome characterized by excessive intra-abdominal fat deposition accompanied by paradoxically low serum cholesterol and triglyceride levels [5].
  • Bodyweights and serum cholesterol and triglyceride levels were compared in SMAM-1-positive (P-AGPT) and SMAM-1-negative (N-AGPT) groups [5].
  • The presence of increased obesity, antibodies to SMAM-1, reduced levels of blood lipids, and viremia that produces a typical infection in chicken embryos suggests that SMAM-1, or a serologically similar human virus, may be involved in the cause of obesity in some humans [5].

Associations of SERF1A with chemical compounds

  • Kainate receptor subunits were identified using a monoclonal antibody (4F5) that recognizes an epitope common to GluR5/6/7 [6].
  • A dilution of the serum fraction of anti-4F antibody was also found to significantly inhibit both S-oxidation and N-demethylation of chlorpromazine by both 4F4 and 4F5 [7].


  1. Infectobesity: obesity of infectious origin. Dhurandhar, N.V. J. Nutr. (2001) [Pubmed]
  2. Human adenovirus Ad-36 promotes weight gain in male rhesus and marmoset monkeys. Dhurandhar, N.V., Whigham, L.D., Abbott, D.H., Schultz-Darken, N.J., Israel, B.A., Bradley, S.M., Kemnitz, J.W., Allison, D.B., Atkinson, R.L. J. Nutr. (2002) [Pubmed]
  3. Contribution of pathogens in human obesity. Dhurandhar, N.V. Drug News Perspect. (2004) [Pubmed]
  4. Identification of a candidate modifying gene for spinal muscular atrophy by comparative genomics. Scharf, J.M., Endrizzi, M.G., Wetter, A., Huang, S., Thompson, T.G., Zerres, K., Dietrich, W.F., Wirth, B., Kunkel, L.M. Nat. Genet. (1998) [Pubmed]
  5. Association of adenovirus infection with human obesity. Dhurandhar, N.V., Kulkarni, P.R., Ajinkya, S.M., Sherikar, A.A., Atkinson, R.L. Obes. Res. (1997) [Pubmed]
  6. Immunocytochemical localization of non-NMDA ionotropic excitatory amino acid receptor subunits in human neocortex. Vickers, J.C., Huntley, G.W., Hof, P.R., Bederson, J., DeFelipe, J., Morrison, J.H. Brain Res. (1995) [Pubmed]
  7. In vitro metabolism of chlorpromazine by cytochromes P450 4F4 and 4F5 and the inhibitory effect of imipramine. Boehme, C.L., Strobel, H.W. Neurotoxicity research. (2001) [Pubmed]
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