Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Sorbs1 - sorbin and SH3 domain containing 1

Mus musculus

Synonyms: 2310065E01Rik, 9530001P15Rik, CAP, Kiaa1296, Ponsin, ...

Ribon, V. et al., Chiang, S.H. et al., Shen, Q. et al., Ribon, V. et al.

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High impact information on Sorbs1

c-Cbl-associated protein (CAP) is a signaling protein that interacts with both c-Cbl and the insulin receptor that may be involved in the specific insulin-stimulated tyrosine phosphorylation of c-Cbl [1].
Activation of both the insulin receptor substrates (IRSs)/Akt and the c-Cbl-associated protein (CAP)/c-Cbl pathways are important in regulating insulin-stimulated glucose transport [2].
c-Cbl-associated protein, CAP, was originally cloned from a 3T3-L1 adipocyte cDNA expression library using full-length c-Cbl as a bait [3].

Other interactions of Sorbs1

Cotransfection of cells with TC10alpha or beta plus a dominant negative form of the c-cbl-associated protein CAP prevented the activation by insulin, implicating the CAP/Cbl pathway [4].

References

Thiazolidinediones and insulin resistance: peroxisome proliferatoractivated receptor gamma activation stimulates expression of the CAP gene. Ribon, V., Johnson, J.H., Camp, H.S., Saltiel, A.R. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
Effects of rexinoids on glucose transport and insulin-mediated signaling in skeletal muscles of diabetic (db/db) mice. Shen, Q., Cline, G.W., Shulman, G.I., Leibowitz, M.D., Davies, P.J. J. Biol. Chem. (2004) [Pubmed]
A role for CAP, a novel, multifunctional Src homology 3 domain-containing protein in formation of actin stress fibers and focal adhesions. Ribon, V., Herrera, R., Kay, B.K., Saltiel, A.R. J. Biol. Chem. (1998) [Pubmed]
Cloning and functional characterization of related TC10 isoforms, a subfamily of Rho proteins involved in insulin-stimulated glucose transport. Chiang, S.H., Hou, J.C., Hwang, J., Pessin, J.E., Saltiel, A.R. J. Biol. Chem. (2002) [Pubmed]

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