Gene Review:
Cbl - Casitas B-lineage lymphoma
Mus musculus
Synonyms:
4732447J05Rik, Casitas B-lineage lymphoma proto-oncogene, Cbl-2, E3 ubiquitin-protein ligase CBL, Proto-oncogene c-Cbl, ...
- p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase. Panchamoorthy, G., Fukazawa, T., Miyake, S., Soltoff, S., Reedquist, K., Druker, B., Shoelson, S., Cantley, L., Band, H. J. Biol. Chem. (1996)
- Tyrosine kinase activity of the EGF receptor is enhanced by the expression of oncogenic 70Z-Cbl. Thien, C.B., Langdon, W.Y. Oncogene (1997)
- Isolation and characterization of a novel, transforming allele of the c-Cbl proto-oncogene from a murine macrophage cell line. Bisson, S.A., Ujack, E.E., Robbins, S.M. Oncogene (2002)
- c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption. Tanaka, S., Amling, M., Neff, L., Peyman, A., Uhlmann, E., Levy, J.B., Baron, R. Nature (1996)
- Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice. Murphy, M.A., Schnall, R.G., Venter, D.J., Barnett, L., Bertoncello, I., Thien, C.B., Langdon, W.Y., Bowtell, D.D. Mol. Cell. Biol. (1998)
- Activated Cdc42 sequesters c-Cbl and prevents EGF receptor degradation. Wu, W.J., Tu, S., Cerione, R.A. Cell (2003)
- Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10. Chiang, S.H., Baumann, C.A., Kanzaki, M., Thurmond, D.C., Watson, R.T., Neudauer, C.L., Macara, I.G., Pessin, J.E., Saltiel, A.R. Nature (2001)
- CAP defines a second signalling pathway required for insulin-stimulated glucose transport. Baumann, C.A., Ribon, V., Kanzaki, M., Thurmond, D.C., Mora, S., Shigematsu, S., Bickel, P.E., Pessin, J.E., Saltiel, A.R. Nature (2000)
- Requirement of SRC-family tyrosine kinases in fat accumulation. Sun, Y., Ma, Y.C., Huang, J., Chen, K.Y., McGarrigle, D.K., Huang, X.Y. Biochemistry (2005)
- APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes. Liu, J., Kimura, A., Baumann, C.A., Saltiel, A.R. Mol. Cell. Biol. (2002)
- The proto-oncogene product p120(cbl) links c-Src and phosphatidylinositol 3'-kinase to the integrin signaling pathway. Ojaniemi, M., Martin, S.S., Dolfi, F., Olefsky, J.M., Vuori, K. J. Biol. Chem. (1997)
- Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase. Hunter, S., Burton, E.A., Wu, S.C., Anderson, S.M. J. Biol. Chem. (1999)
- Impaired plasma membrane targeting of Grb2-murine son of sevenless (mSOS) complex and differential activation of the Fyn-T cell receptor (TCR)-zeta-Cbl pathway mediate T cell hyporesponsiveness in autoimmune nonobese diabetic mice. Salojin, K., Zhang, J., Cameron, M., Gill, B., Arreaza, G., Ochi, A., Delovitch, T.L. J. Exp. Med. (1997)
- Src kinase activity is essential for osteoclast function. Miyazaki, T., Sanjay, A., Neff, L., Tanaka, S., Horne, W.C., Baron, R. J. Biol. Chem. (2004)
- Dynamin forms a Src kinase-sensitive complex with Cbl and regulates podosomes and osteoclast activity. Bruzzaniti, A., Neff, L., Sanjay, A., Horne, W.C., De Camilli, P., Baron, R. Mol. Biol. Cell (2005)
- Phosphorylation of Cbl following stimulation with interleukin-3 and its association with Grb2, Fyn, and phosphatidylinositol 3-kinase. Anderson, S.M., Burton, E.A., Koch, B.L. J. Biol. Chem. (1997)
- RNAi-based analysis of CAP, Cbl, and CrkII function in the regulation of GLUT4 by insulin. Mitra, P., Zheng, X., Czech, M.P. J. Biol. Chem. (2004)
- The roles of Cbl-b and c-Cbl in insulin-stimulated glucose transport. Liu, J., DeYoung, S.M., Hwang, J.B., O'Leary, E.E., Saltiel, A.R. J. Biol. Chem. (2003)
- Tyrosine phosphorylation and translocation of the c-cbl protein after activation of tyrosine kinase signaling pathways. Tanaka, S., Neff, L., Baron, R., Levy, J.B. J. Biol. Chem. (1995)
- Selective defect in antigen-induced TCR internalization at the immune synapse of CD8 T cells bearing the ZAP-70(Y292F) mutation. Davanture, S., Leignadier, J., Milani, P., Soubeyran, P., Malissen, B., Malissen, M., Schmitt-Verhulst, A.M., Boyer, C. J. Immunol. (2005)
- Proto-oncoprotein Vav interacts with c-Cbl in activated thymocytes and peripheral T cells. Marengère, L.E., Mirtsos, C., Kozieradzki, I., Veillette, A., Mak, T.W., Penninger, J.M. J. Immunol. (1997)
- Crkl is complexed with tyrosine-phosphorylated Cbl in Ph-positive leukemia. de Jong, R., ten Hoeve, J., Heisterkamp, N., Groffen, J. J. Biol. Chem. (1995)
- T cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase. Magnan, A., Di Bartolo, V., Mura, A.M., Boyer, C., Richelme, M., Lin, Y.L., Roure, A., Gillet, A., Arrieumerlou, C., Acuto, O., Malissen, B., Malissen, M. J. Exp. Med. (2001)
- c-Cbl localizes to actin lamellae and regulates lamellipodia formation and cell morphology. Scaife, R.M., Langdon, W.Y. J. Cell. Sci. (2000)
- The proto-oncogene c-Cbl is a negative regulator of DNA synthesis initiated by both receptor and cytoplasmic tyrosine kinases. Broome, M.A., Galisteo, M.L., Schlessinger, J., Courtneidge, S.A. Oncogene (1999)
- Distinct roles of p130Cas and c-Cbl in adhesion-induced or macrophage colony-stimulating factor-mediated signaling pathways in prefusion osteoclasts. Nakamura, I., Rodan, G.A., Duong, l.e. .T. Endocrinology (2003)
- Altered thymic positive selection and intracellular signals in Cbl-deficient mice. Naramura, M., Kole, H.K., Hu, R.J., Gu, H. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Direct T cell activation by chimeric single chain Fv-Syk promotes Syk-Cbl association and Cbl phosphorylation. Fitzer-Attas, C.J., Schindler, D.G., Waks, T., Eshhar, Z. J. Biol. Chem. (1997)
- Rapid ubiquitination of Syk following GPVI activation in platelets. Dangelmaier, C.A., Quinter, P.G., Jin, J., Tsygankov, A.Y., Kunapuli, S.P., Daniel, J.L. Blood (2005)
- The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation. Lee, P.S., Wang, Y., Dominguez, M.G., Yeung, Y.G., Murphy, M.A., Bowtell, D.D., Stanley, E.R. EMBO J. (1999)
- TGF-beta, c-Cbl, and PDGFR-alpha the in mammary stroma. Crowley, M.R., Bowtell, D., Serra, R. Dev. Biol. (2005)