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Gene Review:

Sprr1a - small proline-rich protein 1A

Mus musculus

Synonyms: AI528815, Cornifin-A, SPR1 A, SPR1A, SPR1a, ...

Kartasova, T. et al., Iacovoni, J.S. et al., Reddy, S.P. et al., Pradervand, S. et al.

Reddy, Konkin, Wu,

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Disease relevance of Sprr1a

High levels of SPR1a expression were found in epithelia from the forestomach and penis, and in benign squamous papillomas [1].

High impact information on Sprr1a

Small proline-rich protein 1A is a gp130 pathway- and stress-inducible cardioprotective protein [2].
With these cells, we find that the upregulated target Sprr1a has an expression pattern that correlates with the transformed phenotype [3].
Other epithelia expressing SPR1a include the tongue, esophagus, and vagina [1].
Structure and organization of the genes encoding mouse small proline-rich proteins, mSPRR1A and 1B [4].

Analytical, diagnostic and therapeutic context of Sprr1a

Tissues obtained from mouse fetal, newborn, and adult skin were tested by Northern blot analyses, in situ hybridization and immunohistochemistry using an antibody raised to a synthetic peptide corresponding to the C terminus of the SPR1a protein [1].

References

Sequence and expression patterns of mouse SPR1: Correlation of expression with epithelial function. Kartasova, T., Darwiche, N., Kohno, Y., Koizumi, H., Osada, S., Huh, N., Lichti, U., Steinert, P.M., Kuroki, T. J. Invest. Dermatol. (1996) [Pubmed]
Small proline-rich protein 1A is a gp130 pathway- and stress-inducible cardioprotective protein. Pradervand, S., Yasukawa, H., Muller, O.G., Kjekshus, H., Nakamura, T., St Amand, T.R., Yajima, T., Matsumura, K., Duplain, H., Iwatate, M., Woodard, S., Pedrazzini, T., Ross, J., Firsov, D., Rossier, B.C., Hoshijima, M., Chien, K.R. EMBO J. (2004) [Pubmed]
v-Jun targets showing an expression pattern that correlates with the transformed cellular phenotype. Iacovoni, J.S., Cohen, S.B., Berg, T., Vogt, P.K. Oncogene (2004) [Pubmed]
Structure and organization of the genes encoding mouse small proline-rich proteins, mSPRR1A and 1B. Reddy, S.P., Konkin, T., Wu, R. Gene (1998) [Pubmed]

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