Gene Review:
Il6st - interleukin 6 signal transducer
Mus musculus
Synonyms:
5133400A03Rik, AA389424, BB405851, CD130, D13Ertd699e, ...
- Lack of gp130 expression in hepatocytes promotes liver injury. Streetz, K.L., Wüstefeld, T., Klein, C., Kallen, K.J., Tronche, F., Betz, U.A., Schütz, G., Manns, M.P., Müller, W., Trautwein, C. Gastroenterology (2003)
- Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice. Hirota, H., Yoshida, K., Kishimoto, T., Taga, T. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation. Ernst, M., Inglese, M., Waring, P., Campbell, I.K., Bao, S., Clay, F.J., Alexander, W.S., Wicks, I.P., Tarlinton, D.M., Novak, U., Heath, J.K., Dunn, A.R. J. Exp. Med. (2001)
- Contribution of interleukin-6/gp 130 signaling in hepatocytes to the inflammatory response in mice infected with Streptococcus pyogenes. Klein, C., Medina, E., Sander, L., Dierssen, U., Roskams, T., Mueller, W., Trautwein, C., Goldmann, O. J. Infect. Dis. (2007)
- Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling. Jenkins, B.J., Grail, D., Nheu, T., Najdovska, M., Wang, B., Waring, P., Inglese, M., McLoughlin, R.M., Jones, S.A., Topley, N., Baumann, H., Judd, L.M., Giraud, A.S., Boussioutas, A., Zhu, H.J., Ernst, M. Nat. Med. (2005)
- Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Tebbutt, N.C., Giraud, A.S., Inglese, M., Jenkins, B., Waring, P., Clay, F.J., Malki, S., Alderman, B.M., Grail, D., Hollande, F., Heath, J.K., Ernst, M. Nat. Med. (2002)
- The point mutation of tyrosine 759 of the IL-6 family cytokine receptor gp130 synergizes with HTLV-1 pX in promoting rheumatoid arthritis-like arthritis. Ishihara, K., Sawa, S., Ikushima, H., Hirota, S., Atsumi, T., Kamimura, D., Park, S.J., Murakami, M., Kitamura, Y., Iwakura, Y., Hirano, T. Int. Immunol. (2004)
- Surface antigens of melanomas and melanocytes defined by mouse monoclonal antibodies: specificity analysis and comparison of antigen expression in cultured cells and tissues. Real, F.X., Houghton, A.N., Albino, A.P., Cordon-Cardo, C., Melamed, M.R., Oettgen, H.F., Old, L.J. Cancer Res. (1985)
- An epitope on the surface envelope glycoprotein (gp130) of simian immunodeficiency virus (SIVmac) involved in viral neutralization and T cell activation. Torres, J.V., Malley, A., Banapour, B., Anderson, D.E., Axthelm, M.K., Gardner, M.B., Benjamini, E. AIDS Res. Hum. Retroviruses (1993)
- Induction of gp130-related cytokines and activation of JAK2/STAT3 pathway in astrocytes precedes up-regulation of glial fibrillary acidic protein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of neurodegeneration: key signaling pathway for astrogliosis in vivo? Sriram, K., Benkovic, S.A., Hebert, M.A., Miller, D.B., O'Callaghan, J.P. J. Biol. Chem. (2004)
- Interleukin-6/glycoprotein 130-dependent pathways are protective during liver regeneration. Wuestefeld, T., Klein, C., Streetz, K.L., Betz, U., Lauber, J., Buer, J., Manns, M.P., Müller, W., Trautwein, C. J. Biol. Chem. (2003)
- CNTF/LIF/gp130 receptor complex signaling maintains a VZ precursor differentiation gradient in the developing ventral forebrain. Gregg, C., Weiss, S. Development (2005)
- Interleukin-6 signal transducer gp130 has specific binding sites for different cytokines as determined by antagonistic and agonistic anti-gp130 monoclonal antibodies. Wijdenes, J., Heinrich, P.C., Müller-Newen, G., Roche, C., Gu, Z.J., Clément, C., Klein, B. Eur. J. Immunol. (1995)
- Evidence for heterodimeric association of leukemia inhibitory factor (LIF) receptor and gp130 in the mouse uterus for LIF signaling during blastocyst implantation. Song, H., Lim, H. Reproduction (2006)
- Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130. Narazaki, M., Witthuhn, B.A., Yoshida, K., Silvennoinen, O., Yasukawa, K., Ihle, J.N., Kishimoto, T., Taga, T. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Leukemia inhibitory factor, LIF receptor, and gp130 in the mouse uterus during early pregnancy. Yang, Z.M., Le, S.P., Chen, D.B., Cota, J., Siero, V., Yasukawa, K., Harper, M.J. Mol. Reprod. Dev. (1995)
- Astrocyte differentiation of fetal neuroepithelial cells by interleukin-11 via activation of a common cytokine signal transducer, gp130, and a transcription factor, STAT3. Yanagisawa, M., Nakashima, K., Arakawa, H., Ikenaka, K., Yoshida, K., Kishimoto, T., Hisatsune, T., Taga, T. J. Neurochem. (2000)
- Roles of lipid rafts in integrin-dependent adhesion and gp130 signalling pathway in mouse embryonic neural precursor cells. Yanagisawa, M., Nakamura, K., Taga, T. Genes Cells (2004)
- Inverse regulation of interleukin-6 (IL-6) and IL-6 receptor in histamine deficient histidine decarboxylase-knock-out mice. Horváth, B.V., Falus, A., Tóth, S., Szalai, C., Lázár-Molnár, E., Holub, M.C., Buzás, E., Nagy, A., Fulop, A.K. Immunol. Lett. (2002)
- Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death. Ware, C.B., Horowitz, M.C., Renshaw, B.R., Hunt, J.S., Liggitt, D., Koblar, S.A., Gliniak, B.C., McKenna, H.J., Papayannopoulou, T., Thoma, B. Development (1995)
- Identification of ligand-binding site III on the immunoglobulin-like domain of the granulocyte colony-stimulating factor receptor. Layton, J.E., Hall, N.E., Connell, F., Venhorst, J., Treutlein, H.R. J. Biol. Chem. (2001)
- Calmodulin-dependent protein kinases phosphorylate gp130 at the serine-based dileucine internalization motif. Gibson, R.M., Laszlo, G.S., Nathanson, N.M. Biochim. Biophys. Acta (2005)
- SOCS3 regulates the plasticity of gp130 signaling. Lang, R., Pauleau, A.L., Parganas, E., Takahashi, Y., Mages, J., Ihle, J.N., Rutschman, R., Murray, P.J. Nat. Immunol. (2003)
- Glycoprotein 130 signaling regulates Notch1 expression and activation in the self-renewal of mammalian forebrain neural stem cells. Chojnacki, A., Shimazaki, T., Gregg, C., Weinmaster, G., Weiss, S. J. Neurosci. (2003)
- Astrocyte differentiation of fetal neuroepithelial cells involving cardiotrophin-1-induced activation of STAT3. Ochiai, W., Yanagisawa, M., Takizawa, T., Nakashima, K., Taga, T. Cytokine (2001)
- Leukemia inhibitory factor enhances formation of germ cell colonies in neonatal mouse testis culture. Kanatsu-Shinohara, M., Inoue, K., Ogonuki, N., Miki, H., Yoshida, S., Toyokuni, S., Lee, J., Ogura, A., Shinohara, T. Biol. Reprod. (2007)
- Expression of leukemia inhibitory factor receptor and gp130 in mouse uterus during early pregnancy. Ni, H., Ding, N.Z., Harper, M.J., Yang, Z.M. Mol. Reprod. Dev. (2002)
- Regulation of the gp80 and gp130 subunits of the IL-6 receptor by sex steroids in the murine bone marrow. Lin, S.C., Yamate, T., Taguchi, Y., Borba, V.Z., Girasole, G., O'Brien, C.A., Bellido, T., Abe, E., Manolagas, S.C. J. Clin. Invest. (1997)
- Suppressor of cytokine signaling-3 is a biomechanical stress-inducible gene that suppresses gp130-mediated cardiac myocyte hypertrophy and survival pathways. Yasukawa, H., Hoshijima, M., Gu, Y., Nakamura, T., Pradervand, S., Hanada, T., Hanakawa, Y., Yoshimura, A., Ross, J., Chien, K.R. J. Clin. Invest. (2001)