Disease relevance of Srms

• Murine skin is one in which PTK70 was expressed strongly, with its expression being much stronger in the epidermis and in the cell line derived from murine keratinocytes than in those from melanoma or fibroblast cell lines [1].

High impact information on Srms

• A novel nonreceptor tyrosine kinase, Srm: cloning and targeted disruption [2].
• We have isolated a novel nonreceptor tyrosine kinase, Srm, that maps to the distal end of chromosome 2 [2].
• The Srm N-terminal unique domain, however, lacks the structural characteristics of the Tec family kinases, and the sequence similarity is highest to Src in the SH region [2].
• These evidences suggest that PTK70 may be involved in proliferation or differentiation of keratinocytes in the skin [1].

Analytical, diagnostic and therapeutic context of Srms

• When the PCR products were sequenced, a novel clone encoding protein tyrosine kinase, PTK70, was identified [1].

References