Gene Review:
Tdrd5 - tudor domain containing 5
Mus musculus
Synonyms:
Gm103, Tudor domain-containing protein 5
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High impact information on Tdrd5
- In situ hybridization (ISH) on cryosectioned 13.5 dpc testes suggests that expression of Tdrd5, like that of Oct4, is restricted to germ cells [1].
- Expression of Tdrd5 was absent in testes isolated from We/We embryos, which lack germ cells [1].
- Whole-mount in situ hybridization analysis of Tdrd5 expression in the mouse embryonic gonad indicated that this gene is upregulated in the developing testis from 12.5 dpc, with expression levels remaining higher in testis than ovary throughout embryogenesis [1].
Anatomical context of Tdrd5
- Northern hybridization analysis of expression in adult tissues indicated that Tdrd5 is expressed in the testis only, implying that expression of this gene is restricted to the male germline throughout development to adulthood [1].
References
- Expression of the tudor-related gene Tdrd5 during development of the male germline in mice. Smith, J.M., Bowles, J., Wilson, M., Teasdale, R.D., Koopman, P. Gene Expr. Patterns (2004) [Pubmed]
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