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Gene Review

Pou5f1  -  POU domain, class 5, transcription factor 1

Mus musculus

Synonyms: NF-A3, OTF-3, Oct-3, Oct-3/4, Oct-4, ...
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Disease relevance of Pou5f1


High impact information on Pou5f1

  • We identified 1,083 and 3,006 high-confidence binding sites for Oct4 and Nanog, respectively [5].
  • In preimplantation embryos, Cdx2 is initially coexpressed with Oct3/4 and they form a complex for the reciprocal repression of their target genes in ES cells [6].
  • Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues [7].
  • In addition, germ-cell tumors and a few somatic tumors show detectable expression of Oct-4 [7].
  • Here we investigate the effect of ectopic Oct-4 expression on somatic tissues of adult mice using a doxycycline-dependent expression system [7].

Chemical compound and disease context of Pou5f1


Biological context of Pou5f1


Anatomical context of Pou5f1


Associations of Pou5f1 with chemical compounds


Physical interactions of Pou5f1

  • A region of the proximal Oct-4 promoter contains an overlapping set of regulatory elements including a high affinity binding site for Sp1 and three direct repeats of an AGGTCA-like sequence with either +1 or 0 spacing [20].

Co-localisations of Pou5f1

  • LRH-1 is colocalized with Oct4 in the inner cell mass and the epiblast of embryos at early developmental stages [21].

Regulatory relationships of Pou5f1


Other interactions of Pou5f1


Analytical, diagnostic and therapeutic context of Pou5f1


  1. A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Okamoto, K., Okazawa, H., Okuda, A., Sakai, M., Muramatsu, M., Hamada, H. Cell (1990) [Pubmed]
  2. Identification of pulmonary Oct-4+ stem/progenitor cells and demonstration of their susceptibility to SARS coronavirus (SARS-CoV) infection in vitro. Ling, T.Y., Kuo, M.D., Li, C.L., Yu, A.L., Huang, Y.H., Wu, T.J., Lin, Y.C., Chen, S.H., Yu, J. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. Changes in Hox1.6, c-jun, and Oct-3 gene expressions are associated with teratocarcinoma F9 cell differentiation in three different ways of induction. Iwai, S.A., Kosaka, M., Nishina, Y., Sumi, T., Sakuda, M., Nishimune, Y. Exp. Cell Res. (1993) [Pubmed]
  4. Oct-3/4 repression accelerates differentiation of neural progenitor cells in vitro and in vivo. Okuda, T., Tagawa, K., Qi, M.L., Hoshio, M., Ueda, H., Kawano, H., Kanazawa, I., Muramatsu, M., Okazawa, H. Brain Res. Mol. Brain Res. (2004) [Pubmed]
  5. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Loh, Y.H., Wu, Q., Chew, J.L., Vega, V.B., Zhang, W., Chen, X., Bourque, G., George, J., Leong, B., Liu, J., Wong, K.Y., Sung, K.W., Lee, C.W., Zhao, X.D., Chiu, K.P., Lipovich, L., Kuznetsov, V.A., Robson, P., Stanton, L.W., Wei, C.L., Ruan, Y., Lim, B., Ng, H.H. Nat. Genet. (2006) [Pubmed]
  6. Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Niwa, H., Toyooka, Y., Shimosato, D., Strumpf, D., Takahashi, K., Yagi, R., Rossant, J. Cell (2005) [Pubmed]
  7. Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues. Hochedlinger, K., Yamada, Y., Beard, C., Jaenisch, R. Cell (2005) [Pubmed]
  8. A dynamic balance between ARP-1/COUP-TFII, EAR-3/COUP-TFI, and retinoic acid receptor:retinoid X receptor heterodimers regulates Oct-3/4 expression in embryonal carcinoma cells. Ben-Shushan, E., Sharir, H., Pikarsky, E., Bergman, Y. Mol. Cell. Biol. (1995) [Pubmed]
  9. Heterogeneous DNA methylation status of the regulatory element of the mouse Oct4 gene in adult somatic cell population. Marikawa, Y., Fujita, T.C., Alarcón, V.B. Cloning Stem Cells (2005) [Pubmed]
  10. Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1. Zhang, J., Tam, W.L., Tong, G.Q., Wu, Q., Chan, H.Y., Soh, B.S., Lou, Y., Yang, J., Ma, Y., Chai, L., Ng, H.H., Lufkin, T., Robson, P., Lim, B. Nat. Cell Biol. (2006) [Pubmed]
  11. Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Chew, J.L., Loh, Y.H., Zhang, W., Chen, X., Tam, W.L., Yeap, L.S., Li, P., Ang, Y.S., Lim, B., Robson, P., Ng, H.H. Mol. Cell. Biol. (2005) [Pubmed]
  12. New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2. Botquin, V., Hess, H., Fuhrmann, G., Anastassiadis, C., Gross, M.K., Vriend, G., Schöler, H.R. Genes Dev. (1998) [Pubmed]
  13. Oct-3/4 and Sox2 regulate Oct-3/4 gene in embryonic stem cells. Okumura-Nakanishi, S., Saito, M., Niwa, H., Ishikawa, F. J. Biol. Chem. (2005) [Pubmed]
  14. HMG box transcription factor gene Hbp1 is expressed in germ cells of the developing mouse testis. Smith, J.M., Bowles, J., Wilson, M., Koopman, P. Dev. Dyn. (2004) [Pubmed]
  15. Activity-dependent neuroprotective protein: a novel gene essential for brain formation. Pinhasov, A., Mandel, S., Torchinsky, A., Giladi, E., Pittel, Z., Goldsweig, A.M., Servoss, S.J., Brenneman, D.E., Gozes, I. Brain Res. Dev. Brain Res. (2003) [Pubmed]
  16. Oct-4 knockdown induces similar patterns of endoderm and trophoblast differentiation markers in human and mouse embryonic stem cells. Hay, D.C., Sutherland, L., Clark, J., Burdon, T. Stem Cells (2004) [Pubmed]
  17. The oct3 gene, a gene for an embryonic transcription factor, is controlled by a retinoic acid repressible enhancer. Okazawa, H., Okamoto, K., Ishino, F., Ishino-Kaneko, T., Takeda, S., Toyoda, Y., Muramatsu, M., Hamada, H. EMBO J. (1991) [Pubmed]
  18. Epigenetic control of mouse Oct-4 gene expression in embryonic stem cells and trophoblast stem cells. Hattori, N., Nishino, K., Ko, Y.G., Hattori, N., Ohgane, J., Tanaka, S., Shiota, K. J. Biol. Chem. (2004) [Pubmed]
  19. Isolation of murine embryonic stem and embryonic germ cells by selective ablation. Gallagher, E.J., Lodge, P., Ansell, R., McWhir, J. Transgenic Res. (2003) [Pubmed]
  20. Regulation of the Oct-4 gene by nuclear receptors. Sylvester, I., Schöler, H.R. Nucleic Acids Res. (1994) [Pubmed]
  21. Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development. Gu, P., Goodwin, B., Chung, A.C., Xu, X., Wheeler, D.A., Price, R.R., Galardi, C., Peng, L., Latour, A.M., Koller, B.H., Gossen, J., Kliewer, S.A., Cooney, A.J. Mol. Cell. Biol. (2005) [Pubmed]
  22. Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst. Strumpf, D., Mao, C.A., Yamanaka, Y., Ralston, A., Chawengsaksophak, K., Beck, F., Rossant, J. Development (2005) [Pubmed]
  23. Mouse germline restriction of Oct4 expression by germ cell nuclear factor. Fuhrmann, G., Chung, A.C., Jackson, K.J., Hummelke, G., Baniahmad, A., Sutter, J., Sylvester, I., Schöler, H.R., Cooney, A.J. Dev. Cell (2001) [Pubmed]
  24. Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. Yuan, H., Corbi, N., Basilico, C., Dailey, L. Genes Dev. (1995) [Pubmed]
  25. Transplanted embryonic stem cells successfully survive, proliferate, and migrate to damaged regions of the mouse brain. Srivastava, A.S., Shenouda, S., Mishra, R., Carrier, E. Stem Cells (2006) [Pubmed]
  26. Dicer1 expression in preimplantation mouse embryos: Involvement of Oct3/4 transcription at the blastocyst stage. Cui, X.S., Shen, X.H., Kim, N.H. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
  27. Conserved POU binding DNA sites in the Sox2 upstream enhancer regulate gene expression in embryonic and neural stem cells. Catena, R., Tiveron, C., Ronchi, A., Porta, S., Ferri, A., Tatangelo, L., Cavallaro, M., Favaro, R., Ottolenghi, S., Reinbold, R., Schöler, H., Nicolis, S.K. J. Biol. Chem. (2004) [Pubmed]
  28. Expression of the tudor-related gene Tdrd5 during development of the male germline in mice. Smith, J.M., Bowles, J., Wilson, M., Teasdale, R.D., Koopman, P. Gene Expr. Patterns (2004) [Pubmed]
  29. Oct4 is required for primordial germ cell survival. Kehler, J., Tolkunova, E., Koschorz, B., Pesce, M., Gentile, L., Boiani, M., Lomelí, H., Nagy, A., McLaughlin, K.J., Schöler, H.R., Tomilin, A. EMBO Rep. (2004) [Pubmed]
  30. Oct-4 transcription factor is differentially expressed in the mouse embryo during establishment of the first two extraembryonic cell lineages involved in implantation. Palmieri, S.L., Peter, W., Hess, H., Schöler, H.R. Dev. Biol. (1994) [Pubmed]
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