Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

tm - tremulous

Mus musculus

Salamone, J.D. et al., DesGroseillers, L. et al., Kohbata, S. et al.

Salamone, Correa, Carlson, Wisniecki, Mayorga, Nisenbaum, Nisenbaum, Felder,

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Disease relevance of tm

The second group of mice developed a rhythmic, uncontrolled vertical shake of the head (four to five times per s) tremulous movement, stooped posture, restlessness, and no signs of hemiparesis [1].
Neostriatal muscarinic receptor subtypes involved in the generation of tremulous jaw movements in rodents implications for cholinergic involvement in parkinsonism [2].

High impact information on tm

Most mice with a neurological disorder induced with pNEMO-1 MuLV showed a new clinical syndrome not usually seen with the parental Cas-BR-E MuLV: They had no lower limb paralysis but were excessively tremulous, spastic, and immobile [3].
A combination of anatomical and pharmacological research in rats has implicated M4 receptors in the ventrolateral neostriatum in the generation of tremulous jaw movements [2].
Cholinomimetic-induced tremulous jaw movements are suppressed by a number of different antiparkinsonian drugs, including scopolamine, benztropine, L-DOPA, apomorphine, bromocriptine, ropinirole, pergolide, amantadine, diphenhydramine and clozapine [2].

References

L-dopa-responsive movement disorder caused by Nocardia asteroides localized in the brains of mice. Kohbata, S., Beaman, B.L. Infect. Immun. (1991) [Pubmed]
Neostriatal muscarinic receptor subtypes involved in the generation of tremulous jaw movements in rodents implications for cholinergic involvement in parkinsonism. Salamone, J.D., Correa, M., Carlson, B.B., Wisniecki, A., Mayorga, A.J., Nisenbaum, E., Nisenbaum, L., Felder, C. Life Sci. (2001) [Pubmed]
Retrovirus-induced spongiform encephalopathy: the 3'-end long terminal repeat-containing viral sequences influence the incidence of the disease and the specificity of the neurological syndrome. DesGroseillers, L., Rassart, E., Robitaille, Y., Jolicoeur, P. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]

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