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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Paresis

  • Hemicrania with oculosympathetic paresis from isosorbide dinitrate [1].
  • RESULTS: At the time of follow-up, 20 patients (31%) had no neurological deficits, 22 patients (34%) had minor deficits that did not interfere with their daily life activities, and 23 patients (35%) had moderate or severe deficits such as severe ataxia, spastic paresis, seriously reduced vision, or epilepsy with more than two seizures per year [2].
  • In the other seven patients (one with weakness in the arms and legs, one with transient left hemiparesis, two with hearing loss, and three with various visual disturbances), chemotherapeutic agents (mainly cisplatin and vincristine) and underlying diseases probably contributed significantly to the occurrence of these complications [3].
  • Its core elements are a suprabulbar paresis, a mild spastic tetraplegia and a significant excess of cognitive and behavioural impairments and epilepsy [4].
  • Infarction conforming to the interpeduncular profundus arterial territory caused a supranuclear vertical gaze paresis, severe neuropsychological deficits and a delay in the P60 component of the SER [5].

Psychiatry related information on Paresis


High impact information on Paresis

  • Mice that lack NCP1 exhibit tremor, ataxia, and significant motor paresis [11].
  • A combination of three tests with relatively high validity (paresis of abductor pollicis brevis muscle, hyperpathia, and flick sign) did not significantly change the probability of CTS [12].
  • The rat zitter (zi) mutation induces hypomyelination and vacuolation in the central nervous system (CNS), which result in early-onset tremor and progressive flaccid paresis [13].
  • Disease is manifested by ataxia, seizures, and paresis and leads to early death [14].
  • The more marked the paresis of the elbow flexor and extensor muscles of the patients, relative to the strength of the normal subjects, the greater was this reduction in maximum velocity [15].

Chemical compound and disease context of Paresis

  • In all patients anisotropy was reduced in the coronal radiata contralateral to the hemiparesis by more than 3 SD compared to control subjects [16].
  • Oral treatment of rats with N-methyl-l -arginine acetate (l -NMA), beginning at peak disease on day 11 postimmunization, results in significant prolongation of disease and an alteration in the presentation of clinical symptoms from that of solely hind limb paresis/paralysis to severe fore limb involvement as well [17].
  • One patient however, showing minor paresis of one leg, improved after institution of ganciclovir therapy 1 week after onset of symptoms [18].
  • Therapy with acyclovir proved to be successful in animals showing paresis after infection even when the drug was given in lower than optimal dosages [19].
  • We saw a patient with inactive SLE in whom hoarseness and exertional dyspnea developed as a result of arytenoiditis and vocal cord paresis during steroid tapering [20].

Biological context of Paresis


Anatomical context of Paresis


Gene context of Paresis

  • Although IL-6 and sIL-6Ralpha single transgenic mice were free of neurological disease, IL-6/sIL-6Ralpha double-transgenic mice showed neurological signs, such as tremor, gait abnormalities, and paresis [31].
  • RESULTS: Two unrelated patients with PBD without distinctive external features had normal neurodevelopmental milestones during their first year, followed by rapid deterioration including severe hypotonic pareses, seizures, retinopathy, and deafness [32].
  • These results suggest that HGF/SF plays an important role in the development of gastrointestinal paresis and chronic intestinal inflammation [33].
  • This paresis may account in part for the increased BMP-4 activity in fibrodysplasia ossificans progressiva [34].
  • The presentation for AIS1 was hemiparesis in 77% and cerebellar symptoms and seizures in 20%, respectively [35].

Analytical, diagnostic and therapeutic context of Paresis


  1. Hemicrania with oculosympathetic paresis from isosorbide dinitrate. Mueller, R.A., Meienberg, O. N. Engl. J. Med. (1983) [Pubmed]
  2. Long-term neurological outcome of childhood brain tumors treated by surgery only. Sønderkaer, S., Schmiegelow, M., Carstensen, H., Nielsen, L.B., Müller, J., Schmiegelow, K. J. Clin. Oncol. (2003) [Pubmed]
  3. Late neurological complications after prophylactic cranial irradiation in patients with small-cell lung cancer: the Toronto experience. Lishner, M., Feld, R., Payne, D.G., Sagman, U., Sculier, J.P., Pringle, J.F., Yeoh, J.L., Evans, W.K., Shepherd, F.A., Maki, E. J. Clin. Oncol. (1990) [Pubmed]
  4. Worster-Drought syndrome, a mild tetraplegic perisylvian cerebral palsy. Review of 47 cases. Clark, M., Carr, L., Reilly, S., Neville, B.G. Brain (2000) [Pubmed]
  5. Nonhaemorrhagic thalamic infarction. Clinical, neuropsychological and electrophysiological findings in four anatomical groups defined by computerized tomography. Graff-Radford, N.R., Damasio, H., Yamada, T., Eslinger, P.J., Damasio, A.R. Brain (1985) [Pubmed]
  6. Transthyretin amyloidosis: a new mutation associated with dementia. Petersen, R.B., Goren, H., Cohen, M., Richardson, S.L., Tresser, N., Lynn, A., Gali, M., Estes, M., Gambetti, P. Ann. Neurol. (1997) [Pubmed]
  7. Intractable epilepsy in vascular congenital hemiparesis: clinical features and surgical options. Carreño, M., Kotagal, P., Perez Jiménez, A., Mesa, T., Bingaman, W., Wyllie, E. Neurology (2002) [Pubmed]
  8. Neurological abnormalities in Wilson's disease are reversible. Lingam, S., Wilson, J., Nazer, H., Mowat, A.P. Neuropediatrics. (1987) [Pubmed]
  9. Prolonged deficits after focal inhibitory seizures. Bussière, M., Pelz, D., Reid, R.H., Young, G.B. Neurocritical care. (2005) [Pubmed]
  10. Transcallosal resection of hypothalamic hamartomas in patients with intractable epilepsy. Harvey, A.S., Freeman, J.L., Berkovic, S.F., Rosenfeld, J.V. Epileptic disorders : international epilepsy journal with videotape. (2003) [Pubmed]
  11. Axon-glia interactions and the domain organization of myelinated axons requires neurexin IV/Caspr/Paranodin. Bhat, M.A., Rios, J.C., Lu, Y., Garcia-Fresco, G.P., Ching, W., St Martin, M., Li, J., Einheber, S., Chesler, M., Rosenbluth, J., Salzer, J.L., Bellen, H.J. Neuron (2001) [Pubmed]
  12. Efficacy of provocative tests for diagnosis of carpal tunnel syndrome. de Krom, M.C., Knipschild, P.G., Kester, A.D., Spaans, F. Lancet (1990) [Pubmed]
  13. Attractin/mahogany/zitter plays a critical role in myelination of the central nervous system. Kuramoto, T., Kitada, K., Inui, T., Sasaki, Y., Ito, K., Hase, T., Kawagachi, S., Ogawa, Y., Nakao, K., Barsh, G.S., Nagao, M., Ushijima, T., Serikawa, T. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  14. Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha. Probert, L., Akassoglou, K., Pasparakis, M., Kontogeorgos, G., Kollias, G. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  15. Voluntary movement at the elbow in spastic hemiparesis. Fellows, S.J., Kaus, C., Thilmann, A.F. Ann. Neurol. (1994) [Pubmed]
  16. Anisotropy of water diffusion in corona radiata and cerebral peduncle in patients with hemiparesis. Wieshmann, U.C., Clark, C.A., Symms, M.R., Franconi, F., Barker, G.J., Shorvon, S.D. Neuroimage (1999) [Pubmed]
  17. Nitric oxide plays a critical role in the recovery of Lewis rats from experimental autoimmune encephalomyelitis and the maintenance of resistance to reinduction. O'Brien, N.C., Charlton, B., Cowden, W.B., Willenborg, D.O. J. Immunol. (1999) [Pubmed]
  18. Therapy for cytomegalovirus polyradiculomyelitis in patients with AIDS: treatment with ganciclovir. de Gans, J., Portegies, P., Tiessens, G., Troost, D., Danner, S.A., Lange, J.M. AIDS (1990) [Pubmed]
  19. Preventive and curative effects of acyclovir on central nervous system infections in hamsters inoculated with herpes simplex virus. van Ekdom, L.T., Versteeg, J. Am. J. Med. (1982) [Pubmed]
  20. Laryngeal complications in a patient with inactive systemic lupus erythematosus. Korbet, S.M., Block, L.J., Lewis, E.J. Arch. Intern. Med. (1984) [Pubmed]
  21. Evolution of poliovirus type I during 5.5 years of prolonged enteral replication in an immunodeficient patient. Bellmunt, A., May, G., Zell, R., Pring-Akerblom, P., Verhagen, W., Heim, A. Virology (1999) [Pubmed]
  22. TNF-alpha transgenic and knockout models of CNS inflammation and degeneration. Probert, L., Akassoglou, K., Kassiotis, G., Pasparakis, M., Alexopoulou, L., Kollias, G. J. Neuroimmunol. (1997) [Pubmed]
  23. A pre-induction test dose for suxamethonium. Carnie, J. Anaesthesia. (1986) [Pubmed]
  24. Regulation of static and dynamic ocular alignment in patients with trochlear nerve pareses. Lewis, R.F., Zee, D.S., Repka, M.X., Guyton, D.L., Miller, N.R. Vision Res. (1995) [Pubmed]
  25. Stereotypy, locomotor and cataleptic effects produced by drugs influencing dopaminergic systems in a mutant strain of Wistar rats: a genuine model of basal ganglia dysfunction? Turski, L., Schwarz, M., Sontag, K.H. Behav. Brain Res. (1984) [Pubmed]
  26. Bilateral oculomotor paralysis due to neurosyphilis. Jordan, K., Marino, J., Damast, M. Ann. Neurol. (1978) [Pubmed]
  27. Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis. Cali, J.J., Hsieh, C.L., Francke, U., Russell, D.W. J. Biol. Chem. (1991) [Pubmed]
  28. Cocaine and pupillary-sparing oculomotor nerve paresis. Migita, D.S., Devereaux, M.W., Tomsak, R.L. Neurology (1997) [Pubmed]
  29. Unilateral magnetic stimulation of the phrenic nerve. Mills, G.H., Kyroussis, D., Hamnegard, C.H., Wragg, S., Moxham, J., Green, M. Thorax (1995) [Pubmed]
  30. Motor paresis improved by sympathetic block. A motor form of reflex sympathetic dystrophy? Yokota, T., Furukawa, T., Tsukagoshi, H. Arch. Neurol. (1989) [Pubmed]
  31. Astrocytic alterations in interleukin-6/Soluble interleukin-6 receptor alpha double-transgenic mice. Brunello, A.G., Weissenberger, J., Kappeler, A., Vallan, C., Peters, M., Rose-John, S., Weis, J. Am. J. Pathol. (2000) [Pubmed]
  32. Late onset white matter disease in peroxisome biogenesis disorder. Barth, P.G., Gootjes, J., Bode, H., Vreken, P., Majoie, C.B., Wanders, R.J. Neurology (2001) [Pubmed]
  33. Ulcerative proctitis, rectal prolapse, and intestinal pseudo-obstruction in transgenic mice overexpressing hepatocyte growth factor/scatter factor. Takayama, H., Takagi, H., Larochelle, W.J., Kapur, R.P., Merlino, G. Lab. Invest. (2001) [Pubmed]
  34. Paresis of a bone morphogenetic protein-antagonist response in a genetic disorder of heterotopic skeletogenesis. Ahn, J., Serrano de la Pena, L., Shore, E.M., Kaplan, F.S. The Journal of bone and joint surgery. American volume. (2003) [Pubmed]
  35. The first three years of the Swiss Neuropaediatric Stroke Registry (SNPSR): a population-based study of incidence, symptoms and risk factors. Steinlin, M., Pfister, I., Pavlovic, J., Everts, R., Boltshauser, E., Capone Mori, A., Gubser Mercati, D., Hänggeli, C.A., Keller, E., Luetschg, J., Marcoz, J., Ramelli, G.P., Roulet Perez, E., Schmitt-Mechelke, T., Weissert, M. Neuropediatrics. (2005) [Pubmed]
  36. The differential effect of ischemia on the active uptake of dopamine, gamma-aminobutyric acid, and glutamate by brain synaptosomes. Weinberger, J., Cohen, G. J. Neurochem. (1982) [Pubmed]
  37. Use of a portable syringe pump for glucagon administration in abdominal computed tomography. Kreel, L., Bydder, G. Radiology. (1980) [Pubmed]
  38. Convulsions and temporary hemiparesis following spinal anesthesia in a child with moyamoya disease. Yasukawa, M., Yasukawa, K., Akagawa, S., Nakagawa, Y., Miyasaka, K. Anesthesiology (1988) [Pubmed]
  39. Delayed cerebrospinal fluid sterilization and adverse outcome of bacterial meningitis in infants and children. Lebel, M.H., McCracken, G.H. Pediatrics (1989) [Pubmed]
  40. Herpes simplex type 2 encephalitis concurrent with known cerebral metastases. Manz, H.J., Phillips, T.M., McCullough, D.C. Acta Neuropathol. (1979) [Pubmed]
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