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Gene Review

SPDVgp01  -  non-structural polyprotein

Salmon pancreas disease virus

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Disease relevance of SPDVgp01

  • Among animal virus members of this superfamily (the alphavirus and rubivirus genera of the family Togaviridae), the product of this ORF is a nonstructural polyprotein (NSP) that is cleaved by a papain-like cysteine protease (PCP) within the NSP [1].

High impact information on SPDVgp01

  • This sequence of delayed processing of P1234 would explain the accumulation of P123 plus nsP4, the early short-lived minus-strand replicase [2].
  • Besides initiating translation of the nonstructural polyprotein, RNA elements in the 5' 200 bases of the SIN genome RNA, or its complement at the 3' end of the negative-strand intermediate, play key roles in the synthesis of both negative- and positive-strand RNAs [3].
  • Two long open reading frames in the RNA encode a nonstructural polyprotein of 2411 amino acids and a structural polyprotein of 1239 amino acids, respectively [4].
  • Attempts to detect NSP expression and processing in HEV-infected primary monkey hepatocytes were not successful and therefore this proteolytic cleavage could not be authenticated [1].
  • N- and C-terminus-specific immunoprecipitation and deletion mutagenesis were used to determine that the order of these products within the NSP is NH2-78 kDa-107 kDa-COOH [1].

Analytical, diagnostic and therapeutic context of SPDVgp01

  • However, site-specific mutagenesis of Cys483, predicted by computer alignment to be one member of the catalytic dyad of a PCP within the NSP, failed to abolish this cleavage [1].


  1. Expression of the hepatitis E virus ORF1. Ropp, S.L., Tam, A.W., Beames, B., Purdy, M., Frey, T.K. Arch. Virol. (2000) [Pubmed]
  2. Regulation of the sequential processing of Semliki Forest virus replicase polyprotein. Vasiljeva, L., Merits, A., Golubtsov, A., Sizemskaja, V., Kääriäinen, L., Ahola, T. J. Biol. Chem. (2003) [Pubmed]
  3. Selection of functional 5' cis-acting elements promoting efficient sindbis virus genome replication. Gorchakov, R., Hardy, R., Rice, C.M., Frolov, I. J. Virol. (2004) [Pubmed]
  4. Nucleotide sequence of the Barmah Forest virus genome. Lee, E., Stocks, C., Lobigs, P., Hislop, A., Straub, J., Marshall, I., Weir, R., Dalgarno, L. Virology (1997) [Pubmed]
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