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Gene Review

GSX1  -  GS homeobox 1

Homo sapiens

Synonyms: GSH1, Gsh-1, Homeobox protein GSH-1
 
 
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High impact information on GSH1

  • Glutathione (GSH) and homo-GSH (hGSH) are the major low-molecular weight thiols synthesized in Medicago truncatula [1].
  • In plants treated with 1 mM L-buthionine sulphoximine, a potent inhibitor of GSH/hGSH synthesis, only the oxidative stress symptoms appeared, indicating that the depletion of the GSH/hGSH pool was not sufficient to promote cell death, and that other phytotoxic mechanisms might be involved [2].
  • Oxidative stress and cell death increased after exposure for 6-24 h to Cd and Hg, but labelling of GSH/hGSH decreased acutely [2].
  • We also demonstrated a significant effect of EDTA not only on Pb accumulation and metal transport to the aboveground parts but also on the profile and amount of thiol compounds: glutathione (GSH), homoglutathione (hGSH) or phytochelatins (PCs), synthesized by the plants [3].
  • To investigate their substrate tolerance, five GS-like cDNAs have been cloned from plants that can accumulate alternative forms of glutathione, notably soya bean [hGSH (homoglutathione or gamma-glutamyl-L-cysteinyl-beta-alanine)], wheat (hydroxymethylglutathione or gamma-glutamyl-L-cysteinyl-serine) and maize (gamma-Glu-Cys-Glu) [4].

References

  1. A Medicago truncatula homoglutathione synthetase is derived from glutathione synthetase by gene duplication. Frendo, P., Jiménez, M.J., Mathieu, C., Duret, L., Gallesi, D., Van de Sype, G., Hérouart, D., Puppo, A. Plant Physiol. (2001) [Pubmed]
  2. Cellular damage induced by cadmium and mercury in Medicago sativa. Ortega-Villasante, C., Rellán-Alvarez, R., Del Campo, F.F., Carpena-Ruiz, R.O., Hernández, L.E. J. Exp. Bot. (2005) [Pubmed]
  3. Enhancing phytoremediative ability of Pisum sativum by EDTA application. Piechalak, A., Tomaszewska, B., Barałkiewicz, D. Phytochemistry (2003) [Pubmed]
  4. Diversification in substrate usage by glutathione synthetases from soya bean (Glycine max), wheat (Triticum aestivum) and maize (Zea mays). Skipsey, M., Davis, B.G., Edwards, R. Biochem. J. (2005) [Pubmed]
 
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