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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

NAPEPLD  -  N-acyl phosphatidylethanolamine...

Homo sapiens

Synonyms: C7orf18, FMP30, N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D, NAPE-PLD, NAPE-hydrolyzing phospholipase D
 
 
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Disease relevance of NAPE-PLD

 

High impact information on NAPE-PLD

  • Anandamide can be generated from its membrane precursor, N-arachidonoyl phosphatidylethanolamine (NAPE) through cleavage by a phospholipase D (NAPE-PLD) [2].
  • Bacterial endotoxin (LPS)-induced synthesis of anandamide in macrophages is mediated exclusively by the PLC/phosphatase pathway, which is up-regulated by LPS, whereas NAPE-PLD is down-regulated by LPS and functions as a salvage pathway of anandamide synthesis when the PLC/phosphatase pathway is compromised [2].
  • In animal tissues, bioactive N-acylethanolamines including the endocannabinoid anandamide are formed from their corresponding N-acylphosphatidylethanolamines (NAPEs) by the catalysis of a specific phospholipase D (NAPE-PLD) that belongs to the metallo-beta-lactamase family [1].
  • In addition, site-directed mutagenesis studies were addressed to several histidine and aspartic acid residues of NAPE-PLD that are highly conserved within the metallo-beta-lactamase family [1].
  • Thus, NAPE-PLD appeared to function through a mechanism similar to those of the well characterized members of this family but play a unique role in the lipid metabolism of animal tissues [1].
 

Associations of NAPE-PLD with chemical compounds

  • Considering cannabimimetic activities of anandamide, the enzymes involved in the biosynthesis and degradation of anandamide, including NAPE-PLD, may be promising targets for therapeutic agents [3].
 

Other interactions of NAPE-PLD

  • FBXL13 encodes a novel F-box protein, SVHis a member of a gene family that contains Armadillo-like repeats, and NAPE-PLD encodes a phospholipase D-type phosphodiesterase [4].

References

  1. Functional Analysis of the Purified Anandamide-generating Phospholipase D as a Member of the Metallo-beta-lactamase Family. Wang, J., Okamoto, Y., Morishita, J., Tsuboi, K., Miyatake, A., Ueda, N. J. Biol. Chem. (2006) [Pubmed]
  2. A biosynthetic pathway for anandamide. Liu, J., Wang, L., Harvey-White, J., Osei-Hyiaman, D., Razdan, R., Gong, Q., Chan, A.C., Zhou, Z., Huang, B.X., Kim, H.Y., Kunos, G. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. Endocannabinoid-related enzymes as drug targets with special reference to N-acylphosphatidylethanolamine-hydrolyzing phospholipase D. Ueda, N., Okamoto, Y., Tsuboi, K. Current medicinal chemistry. (2005) [Pubmed]
  4. Isolation and analysis of candidate myeloid tumor suppressor genes from a commonly deleted segment of 7q22. Curtiss, N.P., Bonifas, J.M., Lauchle, J.O., Balkman, J.D., Kratz, C.P., Emerling, B.M., Green, E.D., Le Beau, M.M., Shannon, K.M. Genomics (2005) [Pubmed]
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