Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Ulk1 - unc-51 like kinase 1

Mus musculus

Synonyms: AU041434, Serine/threonine-protein kinase ULK1, Serine/threonine-protein kinase Unc51.1, Unc-51-like kinase 1, Unc51.1, ...

Tomoda, T. et al., Zhou, X. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Ulk1

Murine Unc51.1 encodes a novel serine/threonine kinase and is expressed in granule cells in the cerebellar cortex [1].
Thus, Unc51.1 signals the program of gene expression leading to the formation of granule cell axons [1].
Retroviral infection of immature granule cells with a dominant negative Unc51.1 results in inhibition of neurite outgrowth in vitro and in vivo [1].

Physical interactions of Ulk1

NGF can induce the interaction of Ulk1 with TrkA receptor complexes through promoting K63-polyubiquitination of Ulk1 and binding of Ulk1 to the scaffolding protein p62 [2].

References

A mouse serine/threonine kinase homologous to C. elegans UNC51 functions in parallel fiber formation of cerebellar granule neurons. Tomoda, T., Bhatt, R.S., Kuroyanagi, H., Shirasawa, T., Hatten, M.E. Neuron (1999) [Pubmed]
Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons. Zhou, X., Babu, J.R., da Silva, S., Shu, Q., Graef, I.A., Oliver, T., Tomoda, T., Tani, T., Wooten, M.W., Wang, F. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

ULK1	Bos taurus
ULK1	Canis lupus familiaris
ulk1b	Danio rerio
ULK1	Gallus gallus
ULK1	Homo sapiens
LOC709746	Macaca mulatta
ULK1	Pan troglodytes
Ulk1	Rattus norvegicus
ulk1	Xenopus (Silurana) tropicalis

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.