Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

SCUBE3 - signal peptide, CUB domain, EGF-like 3

Homo sapiens

Synonyms: CEGF3, FLJ34743, Signal peptide, CUB and EGF-like domain-containing protein 3

Wu, B.T. et al.

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Disease relevance of SCUBE3

The SCUBE3 gene is mapped to human chromosome 6p21.3, a region that has been linked with the locus for a rare form of metabolic bone disease, Paget's disease of bone 1 [1].

High impact information on SCUBE3

Here we described the identification and characterization of one additional member of the SCUBE family named SCUBE3 in humans, sharing an overall 60% protein identity and a similar domain structure with other family members [1].
When overexpressed in human embryonic kidney 293T cells, the recombinant hSCUBE3 protein is a secreted glycoprotein that can form oligomers tethered to the cell surface [1].

References

A novel secreted, cell-surface glycoprotein containing multiple epidermal growth factor-like repeats and one CUB domain is highly expressed in primary osteoblasts and bones. Wu, B.T., Su, Y.H., Tsai, M.T., Wasserman, S.M., Topper, J.N., Yang, R.B. J. Biol. Chem. (2004) [Pubmed]

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