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Gene Review

SCUBE1  -  signal peptide, CUB domain, EGF-like 1

Homo sapiens

Synonyms: Signal peptide, CUB and EGF-like domain-containing protein 1
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Disease relevance of SCUBE1


High impact information on SCUBE1

  • Here we described the identification and characterization of one additional member of the SCUBE family named SCUBE3 in humans, sharing an overall 60% protein identity and a similar domain structure with other family members [2].
  • SCUBE2 is also a cell-surface protein and can form a heteromeric complex with SCUBE1 [1].
  • As part of a strategy to identify all genes expressed in human EC, a full-length cDNA encoding a potential secreted protein harboring 10 epidermal growth factor (EGF)-like domains and one CUB domain at the carboxyl terminus (termed, SCUBE1 for Signal peptide-CUB-EGF-like domain containing protein 1) was identified [1].
  • SCUBE1 is a secreted glycoprotein that can form oligomers and manifests a stable association with the cell surface [1].
  • Both SCUBE1 and SCUBE2 are rapidly down-regulated in EC after interleukin-1beta and tumor necrosis factor-alpha treatment in vitro and after lipopolysaccharide injection in vivo [1].

Biological context of SCUBE1


Other interactions of SCUBE1

  • OBJECTIVE: The aim of the study was to investigate the protein expression and function of a novel secreted protein in the vascular system, named SCUBE1 for signal peptide, CUB (Complement proteins C1r/C1s, Uegf, and Bmp1) and epidermal growth factor-like (EGF)-like domain containing protein 1 [4].

Analytical, diagnostic and therapeutic context of SCUBE1

  • Interestingly, deposition of SCUBE1 into the subendothelial matrix of the atherosclerotic plaques was evidenced by immunohistochemistry [4].
  • A smaller SCUBE1 fragment, possibly formed by limited proteolysis after being released from the storage granules, was detected in thrombus lysate by Western blot analysis [4].
  • While quantitative real-time RT-PCR verified that the SCUBE1 mRNA is expressed in human platelets, numerous immunolocalization techniques revealed that the preformed SCUBE1 protein is stored in the alpha-granules and translocated to the surface upon platelet stimulation [4].


  1. Identification of a novel family of cell-surface proteins expressed in human vascular endothelium. Yang, R.B., Ng, C.K., Wasserman, S.M., Colman, S.D., Shenoy, S., Mehraban, F., Komuves, L.G., Tomlinson, J.E., Topper, J.N. J. Biol. Chem. (2002) [Pubmed]
  2. A novel secreted, cell-surface glycoprotein containing multiple epidermal growth factor-like repeats and one CUB domain is highly expressed in primary osteoblasts and bones. Wu, B.T., Su, Y.H., Tsai, M.T., Wasserman, S.M., Topper, J.N., Yang, R.B. J. Biol. Chem. (2004) [Pubmed]
  3. Cloning, mapping, and expression analysis of a gene encoding a novel mammalian EGF-related protein (SCUBE1). Grimmond, S., Larder, R., Van Hateren, N., Siggers, P., Hulsebos, T.J., Arkell, R., Greenfield, A. Genomics (2000) [Pubmed]
  4. Localization and characterization of a novel secreted protein SCUBE1 in human platelets. Tu, C.F., Su, Y.H., Huang, Y.N., Tsai, M.T., Li, L.T., Chen, Y.L., Cheng, C.J., Dai, D.F., Yang, R.B. Cardiovasc. Res. (2006) [Pubmed]
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