The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Vdac2  -  voltage-dependent anion channel 2

Mus musculus

Synonyms: Outer mitochondrial membrane protein porin 2, VDAC-2, VDAC-6, Vdac6, Voltage-dependent anion-selective channel protein 2, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Vdac2

  • The channel activity is similar in VDAC1/VDAC3-double-deficient cells and in double-deficient cells with the VDAC2 protein depleted by RNA interference [1].
  • The photolabeled 35-kDa protein in membranes from VDAC-1-deficient mice was identified by two-dimensional electrophoresis and electrospray ionization-tandem mass spectrometry as VDAC-2 [2].
  • Electrophysiological studies also showed that neuroactive steroids modulate GABA(A) receptor function normally in VDAC-2-deficient fibroblasts transfected with alpha(1)beta(2)gamma(2) GABA(A) receptor subunits [2].


  1. Genetic demonstration that the plasma membrane maxianion channel and voltage-dependent anion channels are unrelated proteins. Sabirov, R.Z., Sheiko, T., Liu, H., Deng, D., Okada, Y., Craigen, W.J. J. Biol. Chem. (2006) [Pubmed]
  2. Neuroactive steroid interactions with voltage-dependent anion channels: lack of relationship to GABA(A) receptor modulation and anesthesia. Darbandi-Tonkabon, R., Manion, B.D., Hastings, W.R., Craigen, W.J., Akk, G., Bracamontes, J.R., He, Y., Sheiko, T.V., Steinbach, J.H., Mennerick, S.J., Covey, D.F., Evers, A.S. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
WikiGenes - Universities