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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Vdac2  -  voltage-dependent anion channel 2

Mus musculus

Synonyms: Outer mitochondrial membrane protein porin 2, VDAC-2, VDAC-6, Vdac6, Voltage-dependent anion-selective channel protein 2, ...
 
 
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High impact information on Vdac2

  • The channel activity is similar in VDAC1/VDAC3-double-deficient cells and in double-deficient cells with the VDAC2 protein depleted by RNA interference [1].
  • The photolabeled 35-kDa protein in membranes from VDAC-1-deficient mice was identified by two-dimensional electrophoresis and electrospray ionization-tandem mass spectrometry as VDAC-2 [2].
  • Electrophysiological studies also showed that neuroactive steroids modulate GABA(A) receptor function normally in VDAC-2-deficient fibroblasts transfected with alpha(1)beta(2)gamma(2) GABA(A) receptor subunits [2].

References

  1. Genetic demonstration that the plasma membrane maxianion channel and voltage-dependent anion channels are unrelated proteins. Sabirov, R.Z., Sheiko, T., Liu, H., Deng, D., Okada, Y., Craigen, W.J. J. Biol. Chem. (2006) [Pubmed]
  2. Neuroactive steroid interactions with voltage-dependent anion channels: lack of relationship to GABA(A) receptor modulation and anesthesia. Darbandi-Tonkabon, R., Manion, B.D., Hastings, W.R., Craigen, W.J., Akk, G., Bracamontes, J.R., He, Y., Sheiko, T.V., Steinbach, J.H., Mennerick, S.J., Covey, D.F., Evers, A.S. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
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