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Gene Review:

Vdac3 - voltage-dependent anion channel 3

Mus musculus

Synonyms: Outer mitochondrial membrane protein porin 3, VDAC-3, Voltage-dependent anion-selective channel protein 3, mVDAC3

Darbandi-Tonkabon, R. et al., Sabirov, R.Z. et al., Wu, S. et al.

Sabirov, Sheiko, Liu, Deng, Okada, Craigen,

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High impact information on Vdac3

The channel activity is similar in VDAC1/VDAC3-double-deficient cells and in double-deficient cells with the VDAC2 protein depleted by RNA interference [1].
Photolabeling of 35-kDa protein with [(3)H]6-AziP was reduced 85% in brain membranes prepared from VDAC-1-deficient mice but was unaffected by deficiency of VDAC-3 [2].
Finally, the neuroactive steroid pregnanolone [(3alpha,5beta)-3-hydroxypregnan-20-one] produced anesthesia (loss of righting reflex) in VDAC-1- and VDAC-3-deficient mice, and there was no difference in the recovery time between the VDAC-deficient mice and wild-type controls [2].
VDAC1 and VDAC2 deficient cells exhibit reduced cytochrome c oxidase activity, whereas VDAC3 deficient cells have normal activity [3].

References

Genetic demonstration that the plasma membrane maxianion channel and voltage-dependent anion channels are unrelated proteins. Sabirov, R.Z., Sheiko, T., Liu, H., Deng, D., Okada, Y., Craigen, W.J. J. Biol. Chem. (2006) [Pubmed]
Neuroactive steroid interactions with voltage-dependent anion channels: lack of relationship to GABA(A) receptor modulation and anesthesia. Darbandi-Tonkabon, R., Manion, B.D., Hastings, W.R., Craigen, W.J., Akk, G., Bracamontes, J.R., He, Y., Sheiko, T.V., Steinbach, J.H., Mennerick, S.J., Covey, D.F., Evers, A.S. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
Each mammalian mitochondrial outer membrane porin protein is dispensable: effects on cellular respiration. Wu, S., Sampson, M.J., Decker, W.K., Craigen, W.J. Biochim. Biophys. Acta (1999) [Pubmed]

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