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Gene Review

Cyc1  -  cytochrome c-1

Mus musculus

Synonyms: 2610002H19Rik, AA408921, Complex III subunit 4, Complex III subunit IV, Cytochrome b-c1 complex subunit 4, ...
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Disease relevance of Cyc1


Psychiatry related information on Cyc1


High impact information on Cyc1


Chemical compound and disease context of Cyc1


Biological context of Cyc1


Anatomical context of Cyc1


Associations of Cyc1 with chemical compounds


Physical interactions of Cyc1


Enzymatic interactions of Cyc1


Co-localisations of Cyc1

  • Cleaved caspase-9 first appeared in the cytosol at 2 hours and colocalized with cytochrome c. Terminal deoxynucleotidyl transferase-mediated uridine 5;-triphosphate-biotin nick and labeling (TUNEL) showed significant increase of positive cells in Sod2 -/+ mice compared with the wild-type in the cortex, but not in the caudate putamen [32].

Regulatory relationships of Cyc1


Other interactions of Cyc1


Analytical, diagnostic and therapeutic context of Cyc1


  1. Tacrolimus (FK506) attenuates biphasic cytochrome c release and Bad phosphorylation following transient cerebral ischemia in mice. Li, J.Y., Furuichi, Y., Matsuoka, N., Mutoh, S., Yanagihara, T. Neuroscience (2006) [Pubmed]
  2. OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion. Frezza, C., Cipolat, S., Martins de Brito, O., Micaroni, M., Beznoussenko, G.V., Rudka, T., Bartoli, D., Polishuck, R.S., Danial, N.N., De Strooper, B., Scorrano, L. Cell (2006) [Pubmed]
  3. Changes in energy metabolism of Mycobacterium tuberculosis in mouse lung and under in vitro conditions affecting aerobic respiration. Shi, L., Sohaskey, C.D., Kana, B.D., Dawes, S., North, R.J., Mizrahi, V., Gennaro, M.L. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  4. BID mediates neuronal cell death after oxygen/ glucose deprivation and focal cerebral ischemia. Plesnila, N., Zinkel, S., Le, D.A., Amin-Hanjani, S., Wu, Y., Qiu, J., Chiarugi, A., Thomas, S.S., Kohane, D.S., Korsmeyer, S.J., Moskowitz, M.A. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  5. Time-course of mitochondrial gene expressions in mice brains: implications for mitochondrial dysfunction, oxidative damage, and cytochrome c in aging. Manczak, M., Jung, Y., Park, B.S., Partovi, D., Reddy, P.H. J. Neurochem. (2005) [Pubmed]
  6. Development and cellular applications of fiber optic nitric oxide sensors based on a gold-adsorbed fluorophore. Barker, S.L., Kopelman, R. Anal. Chem. (1998) [Pubmed]
  7. Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. Cipolat, S., Rudka, T., Hartmann, D., Costa, V., Serneels, L., Craessaerts, K., Metzger, K., Frezza, C., Annaert, W., D'Adamio, L., Derks, C., Dejaegere, T., Pellegrini, L., D'Hooge, R., Scorrano, L., De Strooper, B. Cell (2006) [Pubmed]
  8. Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis. Hao, Z., Duncan, G.S., Chang, C.C., Elia, A., Fang, M., Wakeham, A., Okada, H., Calzascia, T., Jang, Y., You-Ten, A., Yeh, W.C., Ohashi, P., Wang, X., Mak, T.W. Cell (2005) [Pubmed]
  9. Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain. Ricci, J.E., Muñoz-Pinedo, C., Fitzgerald, P., Bailly-Maitre, B., Perkins, G.A., Yadava, N., Scheffler, I.E., Ellisman, M.H., Green, D.R. Cell (2004) [Pubmed]
  10. Hepatocyte injury in tyrosinemia type 1 is induced by fumarylacetoacetate and is inhibited by caspase inhibitors. Kubo, S., Sun, M., Miyahara, M., Umeyama, K., Urakami, K., Yamamoto, T., Jakobs, C., Matsuda, I., Endo, F. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  11. Testosterone-mediated sexual dimorphism of the rodent heart. Ventricular lysosomes, mitochondria, and cell growth are modulated by androgens. Koenig, H., Goldstone, A., Lu, C.Y. Circ. Res. (1982) [Pubmed]
  12. Manganese superoxide dismutase mediates the early release of mitochondrial cytochrome C and subsequent DNA fragmentation after permanent focal cerebral ischemia in mice. Fujimura, M., Morita-Fujimura, Y., Kawase, M., Copin, J.C., Calagui, B., Epstein, C.J., Chan, P.H. J. Neurosci. (1999) [Pubmed]
  13. Photosensitization of mitochondrial cytochrome c oxidase by hematoporphyrin derivative and related porphyrins in vitro and in vivo. Gibson, S.L., Hilf, R. Cancer Res. (1983) [Pubmed]
  14. Hypoxia sensitizes cells to nitric oxide-induced apoptosis. Lee, V.Y., McClintock, D.S., Santore, M.T., Budinger, G.R., Chandel, N.S. J. Biol. Chem. (2002) [Pubmed]
  15. Apop-1, a novel protein inducing cyclophilin D-dependent but Bax/Bak-related channel-independent apoptosis. Yasuda, O., Fukuo, K., Sun, X., Nishitani, M., Yotsui, T., Higuchi, M., Suzuki, T., Rakugi, H., Smithies, O., Maeda, N., Ogihara, T. J. Biol. Chem. (2006) [Pubmed]
  16. Anticancer effects of amooranin in human colon carcinoma cell line in vitro and in nude mice xenografts. Ramachandran, C., Nair, P.K., Alamo, A., Cochrane, C.B., Escalon, E., Melnick, S.J. Int. J. Cancer (2006) [Pubmed]
  17. Red wine extract prevents neuronal apoptosis in vitro and reduces mortality of transgenic mice. Amodio, R., Esposito, E., De Ruvo, C., Bellavia, V., Amodio, E., Carruba, G. Ann. N. Y. Acad. Sci. (2006) [Pubmed]
  18. Granzyme B-mediated death of pancreatic beta-cells requires the proapoptotic BH3-only molecule bid. Estella, E., McKenzie, M.D., Catterall, T., Sutton, V.R., Bird, P.I., Trapani, J.A., Kay, T.W., Thomas, H.E. Diabetes (2006) [Pubmed]
  19. Photoreceptor cell apoptosis in the retinal degeneration of Uchl3-deficient mice. Sano, Y., Furuta, A., Setsuie, R., Kikuchi, H., Wang, Y.L., Sakurai, M., Kwon, J., Noda, M., Wada, K. Am. J. Pathol. (2006) [Pubmed]
  20. The role of Ca2+ on the DADS-induced apoptosis in mouse-rat hybrid retina ganglion cells (N18). Lin, H.L., Yang, J.S., Yang, J.H., Fan, S.S., Chang, W.C., Li, Y.C., Chung, J.G. Neurochem. Res. (2006) [Pubmed]
  21. Inhibition of microvascular endothelial cell apoptosis by angiopoietin-1 and the involvement of cytochrome C. Shi, L.G., Zhang, G.P., Jin, H.M. Chin. Med. J. (2006) [Pubmed]
  22. N-benzyladriamycin-14-valerate (AD 198) activates protein kinase C-delta holoenzyme to trigger mitochondrial depolarization and cytochrome c release independently of permeability transition pore opening and Ca2+ influx. Lothstein, L., Savranskaya, L., Barrett, C.M., Israel, M., Sweatman, T.W. Anticancer Drugs (2006) [Pubmed]
  23. Protective effect and mechanism of stronger neo-minophagen C against fulminant hepatic failure. Yang, B.S., Ma, Y.J., Wang, Y., Chen, L.Y., Bi, M.R., Yan, B.Z., Bai, L., Zhou, H., Wang, F.X. World J. Gastroenterol. (2007) [Pubmed]
  24. Role of AMPK{alpha}2 in basal, training-, and AICAR-induced GLUT4, hexokinase II, and mitochondrial protein expression in mouse muscle. J??rgensen, S.B., Treebak, J.T., Viollet, B., Schjerling, P., Vaulont, S., Wojtaszewski, J.F., Richter, E.A. Am. J. Physiol. Endocrinol. Metab. (2007) [Pubmed]
  25. Critical role of acidic sphingomyelinase in murine hepatic ischemia-reperfusion injury. Llacuna, L., Marí, M., Garcia-Ruiz, C., Fernandez-Checa, J.C., Morales, A. Hepatology (2006) [Pubmed]
  26. Differential regulation of the intrinsic pathway of apoptosis in brain and liver during ageing. Stoka, V., Turk, V., Bredesen, D.E. FEBS Lett. (2006) [Pubmed]
  27. Oxidative stress-driven mechanisms of nordihydroguaiaretic acid-induced apoptosis in FL5.12 cells. Deshpande, V.S., Kehrer, J.P. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  28. The relationship between immune interferon production and proliferation in antigen-specific, MHC-restricted T cell lines and clones. Hecht, T.T., Longo, D.L., Matis, L.A. J. Immunol. (1983) [Pubmed]
  29. Clonal analysis of the major histocompatibility complex restriction and the fine specificity of antigen recognition in the T cell proliferative response to cytochrome C. Matis, L.A., Longo, D.L., Hedrick, S.M., Hannum, C., Margoliash, E., Schwartz, R.H. J. Immunol. (1983) [Pubmed]
  30. Mitochondrial contact sites. Lipid composition and dynamics. Ardail, D., Privat, J.P., Egret-Charlier, M., Levrat, C., Lerme, F., Louisot, P. J. Biol. Chem. (1990) [Pubmed]
  31. Ion channel activity of the BH3 only Bcl-2 family member, BID. Schendel, S.L., Azimov, R., Pawlowski, K., Godzik, A., Kagan, B.L., Reed, J.C. J. Biol. Chem. (1999) [Pubmed]
  32. Manganese Superoxide Dismutase Affects Cytochrome c Release and Caspase-9 Activation After Transient Focal Cerebral Ischemia in Mice. Noshita, N., Sugawara, T., Fujimura, M., Morita-Fujimura, Y., Chan, P.H. J. Cereb. Blood Flow Metab. (2001) [Pubmed]
  33. c-MYC apoptotic function is mediated by NRF-1 target genes. Morrish, F., Giedt, C., Hockenbery, D. Genes Dev. (2003) [Pubmed]
  34. Caspase-9 is activated in a cytochrome c-independent manner early during TNFalpha-induced apoptosis in murine cells. McDonnell, M.A., Wang, D., Khan, S.M., Vander Heiden, M.G., Kelekar, A. Cell Death Differ. (2003) [Pubmed]
  35. Bid-induced cytochrome c release is mediated by a pathway independent of mitochondrial permeability transition pore and Bax. Kim, T.H., Zhao, Y., Barber, M.J., Kuharsky, D.K., Yin, X.M. J. Biol. Chem. (2000) [Pubmed]
  36. Bax and Bak independently promote cytochrome C release from mitochondria. Degenhardt, K., Sundararajan, R., Lindsten, T., Thompson, C., White, E. J. Biol. Chem. (2002) [Pubmed]
  37. Tumor necrosis factor regulation of apoptosis in mouse preimplantation embryos and its antagonism by transforming growth factor alpha/phosphatidylionsitol 3-kinase signaling system. Kawamura, K., Kawamura, N., Kumagai, J., Fukuda, J., Tanaka, T. Biol. Reprod. (2007) [Pubmed]
  38. Apoptosis in liver during malaria: role of oxidative stress and implication of mitochondrial pathway. Guha, M., Kumar, S., Choubey, V., Maity, P., Bandyopadhyay, U. FASEB J. (2006) [Pubmed]
  39. Haloperidol induces apoptosis via the sigma2 receptor system and Bcl-XS. Wei, Z., Mousseau, D.D., Dai, Y., Cao, X., Li, X.M. Pharmacogenomics J. (2006) [Pubmed]
  40. Novel triiodophenol derivatives induce caspase-independent mitochondrial cell death in leukemia cells inhibited by Myc. Parreño, M., Vaqué, J.P., Casanova, I., Frade, P., Céspedes, M.V., Pavón, M.A., Molins, A., Camacho, M., Vila, L., Nomdedeu, J.F., Mangues, R., León, J. Mol. Cancer Ther. (2006) [Pubmed]
  41. PUMA is critical for neonatal cardiomyocyte apoptosis induced by endoplasmic reticulum stress. Nickson, P., Toth, A., Erhardt, P. Cardiovasc. Res. (2007) [Pubmed]
  42. The initiator caspase, caspase-10beta, and the BH-3-only molecule, Bid, demonstrate evolutionary conservation in Xenopus of their pro-apoptotic activities in the extrinsic and intrinsic pathways. Kominami, K., Takagi, C., Kurata, T., Kitayama, A., Nozaki, M., Sawasaki, T., Kuida, K., Endo, Y., Manabe, N., Ueno, N., Sakamaki, K. Genes Cells (2006) [Pubmed]
  43. Serum leucine-rich alpha-2-glycoprotein-1 binds cytochrome c and inhibits antibody detection of this apoptotic marker in enzyme-linked immunosorbent assay. Cummings, C., Walder, J., Treeful, A., Jemmerson, R. Apoptosis (2006) [Pubmed]
  44. Coriolus versicolor (Yunzhi) extract attenuates growth of human leukemia xenografts and induces apoptosis through the mitochondrial pathway. Ho, C.Y., Kim, C.F., Leung, K.N., Fung, K.P., Tse, T.F., Chan, H., Lau, C.B. Oncol. Rep. (2006) [Pubmed]
  45. Cytochrome c: immunofluorescent localization of the testis-specific form. Goldberg, E., Sberna, D., Wheat, T.E., Urbanski, G.J., Margoliash, E. Science (1977) [Pubmed]
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