High impact information on Eppk1

• At wound edges in wild-type mice, EPPK was expressed in proliferating keratinocytes in conjunction with keratin 6 [1].
• Epiplakin is dispensable for skin barrier function and for integrity of keratin network cytoarchitecture in simple and stratified epithelia [2].
• Epiplakin, a giant epithelial protein of >700 kDa, belongs to the plakin family of cytolinker proteins [2].
• To investigate epiplakin's biological role, we generated epiplakin-deficient mice by gene targeting in embryonic stem cells [2].
• Epiplakin-deficient mice were viable and fertile, without developing any discernible phenotype [2].

Biological context of Eppk1

• In addition we show on transcript and protein levels that epiplakin is restricted to epithelial tissues and that its gene maps to mouse chromosome 15 (human chromosome 8) [3].

Anatomical context of Eppk1

• Elimination of epiplakin by gene targeting results in acceleration of keratinocyte migration in mice [1].
• In primary cultures of epiplakin-deficient keratinocytes, the organization of actin filaments, microtubules, and keratin networks was found to be normal [2].

Associations of Eppk1 with chemical compounds

• Based on cDNA cloning and sequencing, human epiplakin has been classified as a member of the plakin protein family of cytolinkers [3].

References