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Gene Review:

XRN2 - 5'-3' exoribonuclease 2

Homo sapiens

Synonyms: DHM1-like protein, DHP protein

Zhang, M. et al., Kaneko, S. et al.

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High impact information on XRN2

Cloning and mapping of the XRN2 gene to human chromosome 20p11.1-p11.2 [1].
By radiation hybrid panel mapping, the XRN2 gene was localized to chromosome 20p11.1-p11.2 between markers D20S180 and D20S871 [1].
A 3.6-kb transcript of XRN2 was detected in 16 tissues examined and was more abundant in testis [1].

Other interactions of XRN2

While investigating how XRN2 is recruited to the 3'-processing machinery, we found that XRN2 associates with p54nrb/NonO(p54)-protein-associated splicing factor (PSF), multifunctional proteins involved in several nuclear processes [2].

References

Cloning and mapping of the XRN2 gene to human chromosome 20p11.1-p11.2. Zhang, M., Yu, L., Xin, Y., Hu, P., Fu, Q., Yu, C., Zhao, S. Genomics (1999) [Pubmed]
The multifunctional protein p54nrb/PSF recruits the exonuclease XRN2 to facilitate pre-mRNA 3' processing and transcription termination. Kaneko, S., Rozenblatt-Rosen, O., Meyerson, M., Manley, J.L. Genes Dev. (2007) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AgaP_AGAP004090	Anopheles gambiae str. PEST
XRN3	Arabidopsis thaliana
AGOS_AGR303W	Ashbya gossypii ATCC 10895
XRN2	Bos taurus
xrn-2	Caenorhabditis elegans
XRN2	Canis lupus familiaris
xrn2	Danio rerio
Rat1	Drosophila melanogaster
XRN2	Gallus gallus
KLLA0F07469g	Kluyveromyces lactis NRRL Y-1140
XRN2	Macaca mulatta
MGG_11426	Magnaporthe oryzae 70-15
Xrn2	Mus musculus
NCU01643	Neurospora crassa OR74A
Os01g0872700	Oryza sativa Japonica Group
XRN2	Pan troglodytes
Xrn2	Rattus norvegicus
RAT1	Saccharomyces cerevisiae S288c
dhp1	Schizosaccharomyces pombe 972h-
xrn2	Xenopus (Silurana) tropicalis

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