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Gene Review:

LMTK2 - lemur tyrosine kinase 2

Homo sapiens

Synonyms: AATYK2, Apoptosis-associated tyrosine kinase 2, BREK, Brain-enriched kinase, CDK5/p35-regulated kinase, ...

Wang, H. et al., Wang, H. et al., Penalva, J.C. et al.

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High impact information on LMTK2

Here, we describe the cloning and characterization of a novel human transmembrane protein KPI-2 (Kinase/Phosphatase/Inhibitor-2) that was identified by yeast two-hybrid using protein phosphatase inhibitor-2 (Inh2) as bait [1].
KPI-2 mRNA was predominantly expressed in skeletal muscle [1].
KPI-2 kinase domain has about 60% identity with its closest relative, a tyrosine kinase [1].
Thus, KPI-2 is a kinase with sites to associate with PP1C and Inh2 to form a regulatory complex that is localized to membranes [1].
IP was assessed by means of the lactulose/mannitol (L/M) test, at admission (LMR1), and at the 15th day (LMR2) [2].

Biological context of LMTK2

This study used homogeneous recombinant KPI-2 (Lmr2, LMTK2, Cprk, brain-enriched protein kinase) kinase domain and a library of 1,154 peptides on a microarray to analyze substrate specificity [3].

Associations of LMTK2 with chemical compounds

Peptide Microarray Analysis of Substrate Specificity of the Transmembrane Ser/Thr Kinase KPI-2 Reveals Reactivity with Cystic Fibrosis Transmembrane Conductance Regulator and Phosphorylase [3].

References

A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2. Wang, H., Brautigan, D.L. J. Biol. Chem. (2002) [Pubmed]
A study of intestinal permeability in relation to the inflammatory response and plasma endocab IgM levels in patients with acute pancreatitis. Penalva, J.C., Martínez, J., Laveda, R., Esteban, A., Muñoz, C., Sáez, J., Such, J., Navarro, S., Feu, F., Sánchez-Payá, J., Pérez-Mateo, M. J. Clin. Gastroenterol. (2004) [Pubmed]
Peptide Microarray Analysis of Substrate Specificity of the Transmembrane Ser/Thr Kinase KPI-2 Reveals Reactivity with Cystic Fibrosis Transmembrane Conductance Regulator and Phosphorylase. Wang, H., Brautigan, D.L. Mol. Cell Proteomics (2006) [Pubmed]

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