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Chemical Compound Review

galactitol     hexane-1,2,3,4,5,6-hexol

Synonyms: Mannidex, Mannigen, Gulitol, Hexitol, Mannistol, ...
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Disease relevance of sorbitol


Psychiatry related information on sorbitol

  • Findings in the brains of severely dehydrated animals (water deprivation and mannitol injections for 4 days) were almost identical with those seen after alloxan treatment [6].
  • Outcome measures included response times for an acute head injury to be accepted to a neurosurgical centre; the intensive care bed status; variations in advice given to the referring hospitals with regard to ventilation, use of mannitol, steroids, anticonvulsants, and antibiotics [7].
  • In control goats receiving mannitol during food deprivation, the plasma concentration (mM) decreased from 144 to 140 for Na, 105 to 100 for Cl and from 3.8 to 3.6 for K, but concentrations were restored when these goats were given a load of KCl [8].
  • In late phase II of the MMC cycle (high motor activity), NFT changed significantly in the secretory direction in both Krebs mannitol and Krebs glucose perfused segments, and the perfusate-related difference in transport rate was no longer statistically significant [9].
  • During the conversion reaction, D-sorbitol was added to the reaction mixture at 12-h intervals to maintain the concentration of D-sorbitol at 1.0% [10].

High impact information on sorbitol


Chemical compound and disease context of sorbitol


Biological context of sorbitol


Anatomical context of sorbitol


Associations of sorbitol with other chemical compounds

  • Hyperosmolar solutions containing excess NaCl, mannitol, or sucrose all increased fractional SP release equivalently, in an osmolarity-dependent fashion [30].
  • The hydroxyl radical scavenger, mannitol, significantly depressed ADCC by cells from normals (P < 0.01) but was without effect on cells from CGD patients [24].
  • Conclusions: (1) osmolality is a factor capable of regulating renal tubule bicarbonate absorption; (2) hypertonicity produced with NaCl, urea, or mannitol markedly inhibits bicarbonate absorption in the MTAL; (3) this inhibition occurs independent of, and is additive to, inhibition by vasopressin [31].
  • Raised luminal, but not serosal, osmolality (+/- 150 mM mannitol) decreased Na+ absorption but did not induce Cl- secretion [32].
  • Enhanced M phi anti-Toxoplasma activity was not associated with detectably enhanced superoxide anion generation, nitroblue tetrazolium reduction, or phagolysosome fusion, and was not inhibited by catalase, superoxide dismutase, or mannitol [33].

Gene context of sorbitol


Analytical, diagnostic and therapeutic context of sorbitol


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