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Gene Review

PPP1R2  -  protein phosphatase 1, regulatory...

Homo sapiens

Synonyms: IPP-2, IPP2, Protein phosphatase inhibitor 2
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Disease relevance of PPP1R2


High impact information on PPP1R2


Biological context of PPP1R2


Other interactions of PPP1R2

  • The information on the genomic structure of PPP1R2 is important for exploring this gene as a potential candidate contributing to insulin resistance and NIDDM in other populations [5].


  1. Cloning of the complete coding region for human protein phosphatase inhibitor 2 using the two hybrid system and expression of inhibitor 2 in E. coli. Helps, N.R., Street, A.J., Elledge, S.J., Cohen, P.T. FEBS Lett. (1994) [Pubmed]
  2. Cloning of a cDNA encoding an isoform of human protein phosphatase inhibitor 2 from vascularized breast tumor. Wu, I., Moses, M.A. DNA Seq. (2001) [Pubmed]
  3. Activation of Aurora-A kinase by protein phosphatase inhibitor-2, a bifunctional signaling protein. Satinover, D.L., Leach, C.A., Stukenberg, P.T., Brautigan, D.L. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  4. A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2. Wang, H., Brautigan, D.L. J. Biol. Chem. (2002) [Pubmed]
  5. Genetic analysis of human type 1 protein phosphatase inhibitor 2 in insulin-resistant Pima Indians. Permana, P.A., Mott, D.M. Genomics (1997) [Pubmed]
  6. Cloning and characterization of human phosphatase inhibitor-2 (IPP-2) sequences. Sanséau, P., Jackson, A., Alderton, R.P., Beck, S., Senger, G., Sheer, D., Kelly, A., Trowsdale, J. Mamm. Genome (1994) [Pubmed]
  7. Amino acid sequence at the site on protein phosphatase inhibitor-2, phosphorylated by glycogen synthase kinase-3. Aitken, A., Holmes, C.F., Campbell, D.G., Resink, T.J., Cohen, P., Leung, C.T., Williams, D.H. Biochim. Biophys. Acta (1984) [Pubmed]
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