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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Il22ra1  -  interleukin 22 receptor, alpha 1

Mus musculus

Synonyms: 9130219A07Rik, ENSMUSG00000073746, IL-22 receptor subunit alpha-1, IL-22R, IL-22R-alpha-1, ...
 
 
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Disease relevance of Il22ra1

  • Quantitative real-time reverse transcription-PCR analysis showed marked induction of IL-22 and IL-22 receptor in spleen and kidney during the course of sepsis [1].
  • In this study, we report that murine breast cancer cells express functional IL-22R as indicated by RT-PCR studies, immunoblotting, and STAT3 activation assays [2].
 

High impact information on Il22ra1

  • However, upon lipopolysaccharide stimulation, IL-22R mRNA expression is highly upregulated in the liver, in contrast to CRF2-4, which is expressed constitutively in a variety of tissues [3].
  • The gene was mapped to mouse chromosome 4 in the region syntenic to the human IL-22R gene locus [3].
  • Here, we observe that IL-22R exhibits a restricted expression pattern, with highest levels of mRNA expression in pancreas and detectable expression in multiple other tissues, particularly liver, small intestine, colon, and kidney [4].

References

  1. Inhibition of Interleukin-22 Attenuates Bacterial Load and Organ Failure during Acute Polymicrobial Sepsis. Weber, G.F., Schlautkötter, S., Kaiser-Moore, S., Altmayr, F., Holzmann, B., Weighardt, H. Infect. Immun. (2007) [Pubmed]
  2. IL-22-Mediated Tumor Growth Reduction Correlates with Inhibition of ERK1/2 and AKT Phosphorylation and Induction of Cell Cycle Arrest in the G2-M Phase. Weber, G.F., Gaertner, F.C., Erl, W., Janssen, K.P., Blechert, B., Holzmann, B., Weighardt, H., Essler, M. J. Immunol. (2006) [Pubmed]
  3. Genomic structure and inducible expression of the IL-22 receptor alpha chain in mice. Tachiiri, A., Imamura, R., Wang, Y., Fukui, M., Umemura, M., Suda, T. Genes Immun. (2003) [Pubmed]
  4. Acinar cells of the pancreas are a target of interleukin-22. Aggarwal, S., Xie, M.H., Maruoka, M., Foster, J., Gurney, A.L. J. Interferon Cytokine Res. (2001) [Pubmed]
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