Gene Review:
IL22RA1 - interleukin 22 receptor, alpha 1
Homo sapiens
Synonyms:
CRF2-9, Cytokine receptor class-II member 9, Cytokine receptor family 2 member 9, IL-22 receptor subunit alpha-1, IL-22R-alpha-1, ...
- Inhibition of Interleukin-22 Attenuates Bacterial Load and Organ Failure during Acute Polymicrobial Sepsis. Weber, G.F., Schlautkötter, S., Kaiser-Moore, S., Altmayr, F., Holzmann, B., Weighardt, H. Infect. Immun. (2007)
- IL-22 increases the innate immunity of tissues. Wolk, K., Kunz, S., Witte, E., Friedrich, M., Asadullah, K., Sabat, R. Immunity (2004)
- A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist. Xu, W., Presnell, S.R., Parrish-Novak, J., Kindsvogel, W., Jaspers, S., Chen, Z., Dillon, S.R., Gao, Z., Gilbert, T., Madden, K., Schlutsmeyer, S., Yao, L., Whitmore, T.E., Chandrasekher, Y., Grant, F.J., Maurer, M., Jelinek, L., Storey, H., Brender, T., Hammond, A., Topouzis, S., Clegg, C.H., Foster, D.C. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Radaeva, S., Sun, R., Pan, H.N., Hong, F., Gao, B. Hepatology (2004)
- Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta ) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes. Kotenko, S.V., Izotova, L.S., Mirochnitchenko, O.V., Esterova, E., Dickensheets, H., Donnelly, R.P., Pestka, S. J. Biol. Chem. (2001)
- IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration. Brand, S., Beigel, F., Olszak, T., Zitzmann, K., Eichhorst, S.T., Otte, J.M., Diepolder, H., Marquardt, A., Jagla, W., Popp, A., Leclair, S., Herrmann, K., Seiderer, J., Ochsenkühn, T., Göke, B., Auernhammer, C.J., Dambacher, J. Am. J. Physiol. Gastrointest. Liver Physiol. (2006)
- IL-22, in contrast to IL-10, does not induce Ig production, due to absence of a functional IL-22 receptor on activated human B cells. Lécart, S., Morel, F., Noraz, N., Pène, J., Garcia, M., Boniface, K., Lecron, J.C., Yssel, H. Int. Immunol. (2002)
- Interleukin-22 activates STAT3 and induces IL-10 by colon epithelial cells. Nagalakshmi, M.L., Rascle, A., Zurawski, S., Menon, S., de Waal Malefyt, R. Int. Immunopharmacol. (2004)
- Cloning of a new type II cytokine receptor activating signal transducer and activator of transcription (STAT)1, STAT2 and STAT3. Dumoutier, L., Lejeune, D., Hor, S., Fickenscher, H., Renauld, J.C. Biochem. J. (2003)
