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Gene Review

PLXND1  -  plexin D1

Homo sapiens

Synonyms: KIAA0620, Plexin-D1
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Disease relevance of PLXND1

  • Importantly, we found PLXND1 expression also in a number of human brain tumors, both of primary and metastatic origin [1].
  • Via panning of a phage display library, we isolated two phages that carry single-domain antibodies with specific affinity towards a PLXND1-specific peptide [1].
  • We have performed an extensive mutation analysis on a recently identified positional candidate gene, PLEXIN-D1, for Möbius syndrome 2 mapping to chromosome 3q21-q22 [2].
  • Here we describe, using in situ hybridization, that endothelial plxnD1 expression is regained during tumor angiogenesis in a mouse model of brain metastasis [1].

High impact information on PLXND1


Biological context of PLXND1

  • We characterised the cDNA and predicted protein, and examined the expression pattern during mouse embryogenesis of a positional candidate gene, PLEXIN-D1 (PLXND1) [3].

Analytical, diagnostic and therapeutic context of PLXND1


  1. Plexin D1 expression is induced on tumor vasculature and tumor cells: a novel target for diagnosis and therapy? Roodink, I., Raats, J., van der Zwaag, B., Verrijp, K., Kusters, B., van Bokhoven, H., Linkels, M., de Waal, R.M., Leenders, W.P. Cancer Res. (2005) [Pubmed]
  2. Sequence analysis of the PLEXIN-D1 gene in Möbius syndrome patients. van der Zwaag, B., Verzijl, H.T., Wichers, K.H., Beltran-Valero de Bernabe, D., Brunner, H.G., van Bokhoven, H., Padberg, G.W. Pediatric neurology. (2004) [Pubmed]
  3. PLEXIN-D1, a novel plexin family member, is expressed in vascular endothelium and the central nervous system during mouse embryogenesis. van der Zwaag, B., Hellemons, A.J., Leenders, W.P., Burbach, J.P., Brunner, H.G., Padberg, G.W., Van Bokhoven, H. Dev. Dyn. (2002) [Pubmed]
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