The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Mobius Syndrome

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Mobius Syndrome


High impact information on Mobius Syndrome

  • Use of misoprostol during pregnancy and Möbius' syndrome in infants [1].
  • SOX14 is a candidate gene for limb defects associated with BPES and Möbius syndrome [6].
  • Three congenital disorders have been localised to this region: blepharophimosis-ptosis-epicanthus inversus syndrome (BPES), Charcot-Marie-Tooth neuropathy type IIB (CMT2B) and Mobius syndrome type 2 (MBS2) [7].
  • Moreover, this study underscores the importance of considering FSHD in cases of infantile facial diplegia, especially in patients not demonstrating the full clinical features of Möbius syndrome [8].
  • The pattern of malformations in congenital anomalies such as Möbius syndrome and following prenatal cocaine exposure suggests that there is a zone of vascular vulnerability or ischemic sensitivity in the paramedian region of the developing brain stem [9].

Biological context of Mobius Syndrome


Gene context of Mobius Syndrome


Analytical, diagnostic and therapeutic context of Mobius Syndrome


  1. Use of misoprostol during pregnancy and Möbius' syndrome in infants. Pastuszak, A.L., Schüler, L., Speck-Martins, C.E., Coelho, K.E., Cordello, S.M., Vargas, F., Brunoni, D., Schwarz, I.V., Larrandaburu, M., Safattle, H., Meloni, V.F., Koren, G. N. Engl. J. Med. (1998) [Pubmed]
  2. Uterine contraction in the development of Möbius syndrome. Graf, W.D., Shepard, T.H. J. Child Neurol. (1997) [Pubmed]
  3. Sequence analysis of the PLEXIN-D1 gene in Möbius syndrome patients. van der Zwaag, B., Verzijl, H.T., Wichers, K.H., Beltran-Valero de Bernabe, D., Brunner, H.G., van Bokhoven, H., Padberg, G.W. Pediatric neurology. (2004) [Pubmed]
  4. The puzzle of autism: an ophthalmologic contribution. Miller, M.T., Strömland, K., Gillberg, C., Johansson, M., Nilsson, E.W. Transactions of the American Ophthalmological Society. (1998) [Pubmed]
  5. Dextrocardia and ventricular septal defect in the Möbius syndrome. Caravella, L., Rogers, G.L. Annals of ophthalmology. (1978) [Pubmed]
  6. SOX14 is a candidate gene for limb defects associated with BPES and Möbius syndrome. Wilmore, H.P., Smith, M.J., Wilcox, S.A., Bell, K.M., Sinclair, A.H. Hum. Genet. (2000) [Pubmed]
  7. Fine mapping of the neurally expressed gene SOX14 to human 3q23, relative to three congenital diseases. Hargrave, M., James, K., Nield, K., Toomes, C., Georgas, K., Sullivan, T., Verzijl, H.T., Oley, C.A., Little, M., De Jonghe, P., Kwon, J.M., Kremer, H., Dixon, M.J., Timmerman, V., Yamada, T., Koopman, P. Hum. Genet. (2000) [Pubmed]
  8. Facioscapulohumeral dystrophy presenting as infantile facial diplegia and late-onset limb-girdle myopathy in members of the same family. Felice, K.J., Jones, J.M., Conway, S.R. Muscle Nerve (2005) [Pubmed]
  9. Is there a zone of vascular vulnerability in the fetal brain stem? Leong, S., Ashwell, K.W. Neurotoxicology and teratology. (1997) [Pubmed]
  10. Mobius syndrome associated with ventricular septal defect. Deda, G., Caksen, H., Atalay, S. Indian journal of pediatrics. (2001) [Pubmed]
  11. Strabismus surgery in children with Möbius syndrome. Spierer, A., Barak, A. Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus / American Association for Pediatric Ophthalmology and Strabismus. (2000) [Pubmed]
  12. Möbius syndrome in a patient with alpha 1 antitrypsin deficiency. Beren, R., Davidson, G.P. Australian paediatric journal. (1981) [Pubmed]
WikiGenes - Universities