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Gene Review

RGL1  -  ral guanine nucleotide dissociation...

Homo sapiens

Synonyms: KIAA0959, RGL, Ral guanine nucleotide dissociation stimulator-like 1, RalGDS-like 1
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High impact information on RGL1

  • These results clearly indicate that RID of RGL specifically binds to Ras in mammalian cells, that it blocks the signal from Ras to Raf-1, and that it reverses v-Ras-induced malignant phenotype [1].
  • Furthermore, this action of RGL to stimulate the GDP/GTP exchange of Ral was dependent on Ras in COS cells [2].
  • RGL stimulated the GDP/GTP exchange of Ral and this action was enhanced by the post-translational modification of Ral [2].
  • Transcript A, cloned from liver cDNA libraries has the same amino terminus as the mouse RGL, whereas transcript B cloned from brain has a substitution of 45 amino acids for the first nine amino acids [3].
  • Northern blot analysis shows that human RGL is expressed in a wide variety of tissues with strong expression being seen in the heart, brain, kidney, spleen and testis [3].

Biological context of RGL1

  • Through transgenic modification, we found that DELLA-less versions of GAI (gai) and RGL1 (rgl1) in a Populus tree have profound, dominant effects on phenotype, producing pleiotropic changes in morphology and metabolic profiles [4].

Associations of RGL1 with chemical compounds

  • In COS cells, RGL interacted with RasG12V/E37G (a Ras mutant in which Gly-12 and Glu-37 were changed to Val and Gly, respectively) which failed to bind to Raf, but not with RasG12V/T35S which bound to Raf [2].


  1. Ras-interacting domain of Ral GDP dissociation stimulator like (RGL) reverses v-Ras-induced transformation and Raf-1 activation in NIH3T3 cells. Okazaki, M., Kishida, S., Murai, H., Hinoi, T., Kikuchi, A. Cancer Res. (1996) [Pubmed]
  2. Characterization of Ral GDP dissociation stimulator-like (RGL) activities to regulate c-fos promoter and the GDP/GTP exchange of Ral. Murai, H., Ikeda, M., Kishida, S., Ishida, O., Okazaki-Kishida, M., Matsuura, Y., Kikuchi, A. J. Biol. Chem. (1997) [Pubmed]
  3. The human RGL (RalGDS-like) gene: cloning, expression analysis and genomic organization. Sood, R., Makalowska, I., Carpten, J.D., Robbins, C.M., Stephan, D.A., Connors, T.D., Morgenbesser, S.D., Su, K., Pinkett, H.W., Graham, C.L., Quesenberry, M.I., Baxevanis, A.D., Klinger, K.W., Trent, J.M., Bonner, T.I. Biochim. Biophys. Acta (2000) [Pubmed]
  4. Transgenic modification of gai or rgl1 causes dwarfing and alters gibberellins, root growth, and metabolite profiles in Populus. Busov, V., Meilan, R., Pearce, D.W., Rood, S.B., Ma, C., Tschaplinski, T.J., Strauss, S.H. Planta (2006) [Pubmed]
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