High impact information on Siglech

• By flow cytometry, Siglec-H was expressed specifically on plasmacytoid dendritic cell (pDC) precursors in bone marrow, spleen, blood, and lymph nodes [1].
• Although Siglec-H has the typical structural features required for sialic acid binding, no evidence for carbohydrate recognition was obtained [1].
• Using bone marrow-derived pDC precursors that express Siglec-H, addition of Abs did not influence cytokine production, either in the presence or absence of synthetic oligodeoxynucleotides containing unmethylated cytosine-guanine motifs (CpG) [1].
• Staining of tissue sections showed that Siglec-H was also expressed in a subset of marginal zone macrophages in the spleen and in medullary macrophages in lymph nodes [1].
• Targeting Siglec-H may therefore be a useful way of delivering antigens to pDC precursors for cross-presentation [1].

Anatomical context of Siglech

• Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors [1].

Other interactions of Siglech

• Our molecular cytological studies map the proximal deletion breakpoint between the Luzp2 and Siglec-H loci, and we show that overall mRNA levels of Luzp2 in TgPWS and TgAS brain are significantly reduced by 17% [2].

References