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Gene Review

UBR4  -  ubiquitin protein ligase E3 component n...

Homo sapiens

Synonyms: 600 kDa retinoblastoma protein-associated factor, E3 ubiquitin-protein ligase UBR4, KIAA0462, KIAA1307, N-recognin-4, ...
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Disease relevance of ZUBR1

  • In this article, we identify and characterize p600, a unique 600-kDa retinoblastoma protein- and calmodulin-binding protein [1].

High impact information on ZUBR1


Biological context of ZUBR1

  • Depletion of p600 protein levels by RNA interference substantially decreased anchorage-independent growth in HPV-positive and -negative human cancer cells [2].
  • In the cytoplasm, p600 and clathrin form a meshwork structure, which could contribute to cytoskeletal organization and membrane morphogenesis [1].


  1. p600, a unique protein required for membrane morphogenesis and cell survival. Nakatani, Y., Konishi, H., Vassilev, A., Kurooka, H., Ishiguro, K., Sawada, J., Ikura, T., Korsmeyer, S.J., Qin, J., Herlitz, A.M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600. Huh, K.W., DeMasi, J., Ogawa, H., Nakatani, Y., Howley, P.M., Münger, K. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
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