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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

KIAA0368  -  KIAA0368

Homo sapiens

Synonyms: ECM29, Ecm29, FLJ22036, Proteasome-associated protein ECM29 homolog
 
 
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High impact information on KIAA0368

  • The antibodies show that Ecm29 is present exclusively on 26 S proteasomes in HeLa cells and that Ecm29 levels vary markedly among mouse organs [1].
  • Ecm29 is up-regulated 2-3-fold in toxinresistant mutant CHO cells exhibiting increased rates of ER-associated degradation [1].
  • These observations lead us to speculate on how PA200 and Ecm29 may associate with proteasomes [2].
  • Results identified adipose differentiation-related protein (ADRP) as up-regulated by both irritant and allergen, and KIAA0368 as selectively up-regulated by contact allergen [3].

References

  1. Characterization of mammalian Ecm29, a 26 S proteasome-associated protein that localizes to the nucleus and membrane vesicles. Gorbea, C., Goellner, G.M., Teter, K., Holmes, R.K., Rechsteiner, M. J. Biol. Chem. (2004) [Pubmed]
  2. New HEAT-like repeat motifs in proteins regulating proteasome structure and function. Kajava, A.V., Gorbea, C., Ortega, J., Rechsteiner, M., Steven, A.C. J. Struct. Biol. (2004) [Pubmed]
  3. Use of differential display-polymerase chain reaction to identify genes selectively modulated by chemical allergens in reconstituted human epidermis. Corsini, E., Sheasgreen, J., Marinovich, M., Galli, C.L. Toxicology in vitro : an international journal published in association with BIBRA. (2002) [Pubmed]
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