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Gene Review

PSME4  -  proteasome (prosome, macropain) activator...

Homo sapiens

Synonyms: KIAA0077, PA200, Proteasome activator PA200, Proteasome activator complex subunit 4
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Disease relevance of PSME4


High impact information on PSME4

  • PA28 and PA200 are activators that bind to proteasomes and stimulate the hydrolysis of peptides [2].
  • Taken together, these findings implicate PA200 in DNA repair, possibly by recruiting proteasomes to double strand breaks [1].
  • Following gamma-irradiation of HeLa cells the uniform nuclear distribution of PA200 changes to a strikingly punctate pattern, a behavior characteristic of many DNA repair proteins [1].
  • These observations lead us to speculate on how PA200 and Ecm29 may associate with proteasomes [3].
  • We developed an easy method to evaluate the existence and extent of NMAs and the subsequent spontaneous platelet aggregation (SPA) induced by not any agonist but stirring force with a novel platelet aggregometer (PA-200; Kowa, Tsukuba, Japan) employing a particle-counting method based on laser light scattering [4].

Biological context of PSME4

  • The protein, which we call PA200, has been purified to homogeneity from bovine testis and has been shown to activate proteasomal hydrolysis of peptides, but not proteins [1].

Anatomical context of PSME4

  • At least 36 distinct subunits (17 of 20S and 19 of 19S) are coexpressed and assembled as 26S proteasomes in this vital cardiac organelle, whereas the expression of PA200 and 11S subunits were detected with limited participation in the 26S complexes [5].

Associations of PSME4 with chemical compounds

  • From 1981-1997 there were 86 ejections from 56 aircraft within the German Air Force. Of these, 24 accidents were associated with the F-104 Starfighter, 14 with the PA 200 Tornado, 12 from the F-4 Phantom, 5 from the Alpha Jet and 1 from a MiG 29 Fulcrum [6].


  1. PA200, a nuclear proteasome activator involved in DNA repair. Ustrell, V., Hoffman, L., Pratt, G., Rechsteiner, M. EMBO J. (2002) [Pubmed]
  2. Mobilizing the proteolytic machine: cell biological roles of proteasome activators and inhibitors. Rechsteiner, M., Hill, C.P. Trends Cell Biol. (2005) [Pubmed]
  3. New HEAT-like repeat motifs in proteins regulating proteasome structure and function. Kajava, A.V., Gorbea, C., Ortega, J., Rechsteiner, M., Steven, A.C. J. Struct. Biol. (2004) [Pubmed]
  4. A new system to detect native microaggregates of platelets in vivo, with a novel platelet aggregometer employing laser light scattering. Tomida, Y., Iino, S., Nishikawa, M., Hidaka, H. Thromb. Res. (1998) [Pubmed]
  5. Mapping the murine cardiac 26S proteasome complexes. Gomes, A.V., Zong, C., Edmondson, R.D., Li, X., Stefani, E., Zhang, J., Jones, R.C., Thyparambil, S., Wang, G.W., Qiao, X., Bardag-Gorce, F., Ping, P. Circ. Res. (2006) [Pubmed]
  6. Ejection associated injuries within the German Air Force from 1981-1997. Werner, U. Aviation, space, and environmental medicine. (1999) [Pubmed]
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