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Gene Review:

CES3 - carboxylesterase 3

Homo sapiens

Synonyms: Carboxylesterase 3, ES31, FLJ21736, Liver carboxylesterase 31 homolog, UNQ869/PRO1887

Quinney, S.K. et al., Sun, Z. et al., Sanghani, S.P. et al., Sanghani, S.P. et al.

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High impact information on CES3

EXPERIMENTAL DESIGN: We investigated 24 colon tumors for expression of carboxylesterases CES1A1, CES2, CES3, hBr-3, and topoisomerase I genes by real-time PCR and correlated the gene expression with activity assays [1].
Little catalytic activity is detected for CES3 with capecitabine [2].
This study examines the steady-state kinetics of recombinant human carboxylesterase isozymes carboxylesterase (CES) 1A1, CES2, and CES3 for hydrolysis of capecitabine with a liquid chromatography/mass spectroscopy assay [2].
Accordingly, the kinetics of hydrolysis of individual enantiomers by purified native and recombinant human liver carboxylesterases CES1A1 and CES2 and a colon isoenzyme CES3 were examined with a liquid chromatography/mass spectrometry assay [3].

Biological context of CES3

Catalytic efficiency of CES3 for CPT-11 hydrolysis was 20- to 2000-fold less than that of CES1A1 and CES2 [4].

Analytical, diagnostic and therapeutic context of CES3

Northern blot analysis indicates that relative expression in intestinal tissue is CES2 > CES1A1 > CES3 [2].

References

Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis. Sanghani, S.P., Quinney, S.K., Fredenburg, T.B., Sun, Z., Davis, W.I., Murry, D.J., Cummings, O.W., Seitz, D.E., Bosron, W.F. Clin. Cancer Res. (2003) [Pubmed]
Hydrolysis of capecitabine to 5'-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide. Quinney, S.K., Sanghani, S.P., Davis, W.I., Hurley, T.D., Sun, Z., Murry, D.J., Bosron, W.F. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
Methylphenidate is stereoselectively hydrolyzed by human carboxylesterase CES1A1. Sun, Z., Murry, D.J., Sanghani, S.P., Davis, W.I., Kedishvili, N.Y., Zou, Q., Hurley, T.D., Bosron, W.F. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3. Sanghani, S.P., Quinney, S.K., Fredenburg, T.B., Davis, W.I., Murry, D.J., Bosron, W.F. Drug Metab. Dispos. (2004) [Pubmed]

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CES3	Bos taurus
Ces3a	Mus musculus
Ces3b	Mus musculus
CES3	Pan troglodytes
Ces3a	Rattus norvegicus

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