High impact information on ZMYND8

• The hepatitis B virus X-associated protein, XAP3, is a protein kinase C-binding protein [1].
• The PRKCBP1 gene has been localized to human Chromosome (Chr) 20q12-13 [2].
• SSCP analysis was used to screen PRKCBP1 coding regions for mutations or polymorphisms in 100 Caucasian Type II diabetics and 100 Caucasian unaffected individuals [2].
• We determined the PRKCBP1 coding sequence is 1845 bp in length, dispersed over 9 exons, spanning approximately 34 kb of genomic DNA [2].
• Using a monoclonal antibody to RACK1 in the screening of a human hippocampus cDNA library, we identified a novel member of the RACK family, designated PRKCBP1 [2].

Biological context of ZMYND8

• The cDNA sequence of gravin was homologous with rat mitogenic regulatory gene or rat protein kinase C binding protein and substrate, suggesting that gravin would regulate cell growth [3].

Anatomical context of ZMYND8

• Northern analysis detected a 3.1-kb PRKCBP1 transcript in all tissues examined including brain, heart, liver, lung, pancreas, skeletal muscle, kidney, and spleen [2].

Analytical, diagnostic and therapeutic context of ZMYND8

• Immunoprecipitation assays performed with a GST-fused PRKCBP1 protein suggest the carboxy terminus of PRKCBP1 interacts specifically with PKCbetaI [2].

References