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RSF1  -  remodeling and spacing factor 1

Homo sapiens

Synonyms: HBV pX-associated protein 8, HBXAP, Hepatitis B virus X-associated protein, RSF-1, Remodeling and spacing factor 1, ...
 
 
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Disease relevance of RSF1

  • The sequence of the gene for Rsf-1 includes a recently characterized cDNA, HBXAP; postulated to be involved in the transcriptional regulation of the hepatitis B virus [1].
  • Identification of remodeling and spacing factor 1 (rsf-1, HBXAP) at chromosome 11q13 as a putative oncogene in ovarian cancer [2].
  • Rsf-1 expression level was significantly lower in primary tumors and solid metastases (P < 0.001 for extent, intensity and score) [3].
 

High impact information on RSF1

 

Biological context of RSF1

 

Anatomical context of RSF1

 

Associations of RSF1 with chemical compounds

 

Other interactions of RSF1

References

  1. Functional analysis of the subunits of the chromatin assembly factor RSF. Loyola, A., Huang, J.Y., LeRoy, G., Hu, S., Wang, Y.H., Donnelly, R.J., Lane, W.S., Lee, S.C., Reinberg, D. Mol. Cell. Biol. (2003) [Pubmed]
  2. Identification of remodeling and spacing factor 1 (rsf-1, HBXAP) at chromosome 11q13 as a putative oncogene in ovarian cancer. Hennessy, B.T., Nanjundan, M., Cheng, K.W., Nolden, L., Mills, G.B. Eur. J. Hum. Genet. (2006) [Pubmed]
  3. Expression of the chromatin remodeling factor Rsf-1 is upregulated in ovarian carcinoma effusions and predicts poor survival. Davidson, B., Trope', C.G., Wang, T.L., Shih, I.e.M. Gynecol. Oncol. (2006) [Pubmed]
  4. Amplification of a chromatin remodeling gene, Rsf-1/HBXAP, in ovarian carcinoma. Shih, I.e.M., Sheu, J.J., Santillan, A., Nakayama, K., Yen, M.J., Bristow, R.E., Vang, R., Parmigiani, G., Kurman, R.J., Trope, C.G., Davidson, B., Wang, T.L. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  5. Hepatitis B virus X-associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activity. Meyer, B.K., Pray-Grant, M.G., Vanden Heuvel, J.P., Perdew, G.H. Mol. Cell. Biol. (1998) [Pubmed]
  6. Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription. Shamay, M., Barak, O., Doitsh, G., Ben-Dor, I., Shaul, Y. J. Biol. Chem. (2002) [Pubmed]
  7. Functional interaction between nuclear matrix-associated HBXAP and NF-kappaB. Huang, J.Y., Shen, B.J., Tsai, W.H., Lee, S.C. Exp. Cell Res. (2004) [Pubmed]
  8. HBXAP, a novel PHD-finger protein, possesses transcription repression activity. Shamay, M., Barak, O., Shaul, Y. Genomics (2002) [Pubmed]
  9. The transactivation domain of the Ah receptor is a key determinant of cellular localization and ligand-independent nucleocytoplasmic shuttling properties. Ramadoss, P., Perdew, G.H. Biochemistry (2005) [Pubmed]
  10. The hepatitis B virus X-associated protein, XAP3, is a protein kinase C-binding protein. Cong, Y.S., Yao, Y.L., Yang, W.M., Kuzhandaivelu, N., Seto, E. J. Biol. Chem. (1997) [Pubmed]
 
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