The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • OMIM
  • SNPedia
  • UniProt
  • Ensembl
  • HGNC

Table of contents

About

Terms

 

Gene Review: 

TMEM2  -  transmembrane protein 2

Homo sapiens

Synonyms: KIAA1412, Transmembrane protein 2
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of TMEM2

 

High impact information on TMEM2

  • Fibrocystin-L has extracellular domains similar to fibrocystin with 14 copies of the TIG domain and two regions of significant homology to the protein TMEM2 [2].
  • This beta-catenin-associated expression of AhR and transmembrane protein 2 does not require de novo protein synthesis and may only involve a certain subset of CaP cell lines [3].
  • All DNA variants that segregated with the deafness and changed the predicted amino acid sequence of TMEM2 were common polymorphisms, as demonstrated by allele-specific amplification of pooled control DNA [4].
  • We have determined the cDNA sequence and genomic structure of a novel gene, TMEM2, that maps to this interval and is expressed in the cochlea [4].
  • Refining the DFNB7-DFNB11 deafness locus using intragenic polymorphisms in a novel gene, TMEM2 [4].
 

Biological context of TMEM2

  • The mouse orthologue of this gene (Tmem2) maps to the murine dn (deafness) locus on mouse chromosome 19 [4].
 

Other interactions of TMEM2

  • We report a novel protein domain-G8-which contains five repeated beta-strand pairs and is present in some disease-related proteins such as PKHD1, KIAA1199, TMEM2 as well as other uncharacterized proteins [1].
 

Analytical, diagnostic and therapeutic context of TMEM2

  • Northern blot analysis showed no difference in transcript size or expression level of Tmem2 in dn/dn and control mice [4].

References

  1. G8: a novel domain associated with polycystic kidney disease and non-syndromic hearing loss. He, Q.Y., Liu, X.H., Li, Q., Studholme, D.J., Li, X.W., Liang, S.P. Bioinformatics (2006) [Pubmed]
  2. PKHDL1, a homolog of the autosomal recessive polycystic kidney disease gene, encodes a receptor with inducible T lymphocyte expression. Hogan, M.C., Griffin, M.D., Rossetti, S., Torres, V.E., Ward, C.J., Harris, P.C. Hum. Mol. Genet. (2003) [Pubmed]
  3. Identification of aryl hydrocarbon receptor as a putative Wnt/beta-catenin pathway target gene in prostate cancer cells. Chesire, D.R., Dunn, T.A., Ewing, C.M., Luo, J., Isaacs, W.B. Cancer Res. (2004) [Pubmed]
  4. Refining the DFNB7-DFNB11 deafness locus using intragenic polymorphisms in a novel gene, TMEM2. Scott, D.A., Drury, S., Sundstrom, R.A., Bishop, J., Swiderski, R.E., Carmi, R., Ramesh, A., Elbedour, K., Srikumari Srisailapathy, C.R., Keats, B.J., Sheffield, V.C., Smith, R.J. Gene (2000) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities