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Gene Review:

Aldh8a1 - aldehyde dehydrogenase 8 family, member A1

Mus musculus

Synonyms: Aldehyde dehydrogenase family 8 member A1, RALDH4, Raldh4, Retinal dehydrogenase 4

Lin, M. et al.

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High impact information on Aldh8a1

Immunohistochemistry confirmed RALDH4 expression in hepatocytes and showed that hepatocytes also express RALDH1, RALDH2, and RALDH3 [1].
Mouse retinal dehydrogenase 4 (RALDH4), molecular cloning, cellular expression, and activity in 9-cis-retinoic acid biosynthesis in intact cells [1].
RALDH4 recognizes as substrate 9-cis-retinal generated in transfected cells by the short-chain dehydrogenases CRAD1, CRAD3, or RDH1, to reconstitute a path of 9-cis-retinoic acid biosynthesis in situ [1].

Anatomical context of Aldh8a1

In situ hybridization revealed expression of RALDH4 in liver on embryo day 14.5, in adult hepatocytes, and kidney cortex [1].

Associations of Aldh8a1 with chemical compounds

The enzymatic characteristics of RALDH4, its expression in fetal liver, and its unique expression pattern in adult kidney compared with RALDH1, -2, and -3 suggest that it could meet specific needs for 9-cis-retinoic acid biosynthesis [1].

Analytical, diagnostic and therapeutic context of Aldh8a1

Northern blot analysis showed expression of RALDH4 mRNA in adult mouse liver and kidney [1].

References

Mouse retinal dehydrogenase 4 (RALDH4), molecular cloning, cellular expression, and activity in 9-cis-retinoic acid biosynthesis in intact cells. Lin, M., Zhang, M., Abraham, M., Smith, S.M., Napoli, J.L. J. Biol. Chem. (2003) [Pubmed]

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