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MeSH Review

Kidney Cortex

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Disease relevance of Kidney Cortex


High impact information on Kidney Cortex

  • Immunofluorescence studies in human kidney cortex revealed that ATP6N1B localizes almost exclusively to the apical surface of -intercalated cells [6].
  • Recently, we found that testosterone induces an early (less than 60s), Ca2+- and receptor-dependent stimulation of endocytosis, hexose transport and amino acid transport in mouse kidney cortex involving the proximal tubules [7].
  • We now report that testosterone evokes a rapid (less than 30 s), transient increase in ODC activity and a sustained increase in polyamines in kidney cortex [7].
  • Expression of cPLA(2) results in dispersion of giantin and beta-COP from their normal, condensed Golgi localization, and in marked disruption of the Golgi cisternae. cPLA(2) is present in Golgi fractions from noninfected LLC-PK(1) cells and rat kidney cortex [8].
  • Total RNAs were isolated from both duodenum and kidney cortex, and the VDR and calbindin mRNA levels were determined by Northern blot hybridization using specific cDNA probes [9].

Chemical compound and disease context of Kidney Cortex


Biological context of Kidney Cortex


Anatomical context of Kidney Cortex


Associations of Kidney Cortex with chemical compounds


Gene context of Kidney Cortex

  • Nox4 protein expression was increased in diabetic kidney cortex compared with non-diabetic controls and was down-regulated in AS-treated animals [29].
  • Identification of endothelin receptor subtypes in rat kidney cortex using subtype-selective ligands [30].
  • COX-2 expression in kidney cortex was assessed by immunohistochemical staining and by semiquantitative ribonuclease protection assay for COX-2 mRNA [31].
  • Most of the tumors (65%) exhibited higher cyclin E levels than corresponding normal kidney cortex tissues [32].
  • METHODS: The kidney cortex and medulla of male and female RLX+/+ and RLX-/- mice at various ages were analyzed for collagen content, concentration, and types [33].

Analytical, diagnostic and therapeutic context of Kidney Cortex


  1. DNase I-like endonuclease in rat kidney cortex that is activated during ischemia/reperfusion injury. Basnakian, A.G., Ueda, N., Kaushal, G.P., Mikhailova, M.V., Shah, S.V. J. Am. Soc. Nephrol. (2002) [Pubmed]
  2. cDNA cloning and expression of a novel family of enzymes with calcium-independent phospholipase A2 and lysophospholipase activities. Portilla, D., Crew, M.D., Grant, D., Serrero, G., Bates, L.M., Dai, G., Sasner, M., Cheng, J., Buonanno, A. J. Am. Soc. Nephrol. (1998) [Pubmed]
  3. Factors that control the tissue-specific transcription of the gene for phosphoenolpyruvate carboxykinase-C. Chakravarty, K., Cassuto, H., Reshef, L., Hanson, R.W. Crit. Rev. Biochem. Mol. Biol. (2005) [Pubmed]
  4. Renal and microvascular effects of an aldose reductase inhibitor in experimental diabetes. Biochemical, functional and ultrastructural studies. Kassab, J.P., Guillot, R., Andre, J., Claperon, N., Bellon, G., Feldmann, G., Peyroux, J., Sternberg, M. Biochem. Pharmacol. (1994) [Pubmed]
  5. The effects of administering quinacrine during ultraprofound hypothermia on warm ischemic kidney cortex tissue. McAnulty, J.F., Huang, X.Q. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  6. Mutations in ATP6N1B, encoding a new kidney vacuolar proton pump 116-kD subunit, cause recessive distal renal tubular acidosis with preserved hearing. Smith, A.N., Skaug, J., Choate, K.A., Nayir, A., Bakkaloglu, A., Ozen, S., Hulton, S.A., Sanjad, S.A., Al-Sabban, E.A., Lifton, R.P., Scherer, S.W., Karet, F.E. Nat. Genet. (2000) [Pubmed]
  7. Polyamines regulate calcium fluxes in a rapid plasma membrane response. Koenig, H., Goldstone, A., Lu, C.Y. Nature (1983) [Pubmed]
  8. Cytosolic phospholipase A(2) regulates golgi structure and modulates intracellular trafficking of membrane proteins. Choukroun, G.J., Marshansky, V., Gustafson, C.E., McKee, M., Hajjar, R.J., Rosenzweig, A., Brown, D., Bonventre, J.V. J. Clin. Invest. (2000) [Pubmed]
  9. Hyperresponsiveness of vitamin D receptor gene expression to 1,25-dihydroxyvitamin D3. A new characteristic of genetic hypercalciuric stone-forming rats. Yao, J., Kathpalia, P., Bushinsky, D.A., Favus, M.J. J. Clin. Invest. (1998) [Pubmed]
  10. Effect of hyperfiltration, proteinuria and diabetes mellitus on the uptake kinetics of gentamicin in the kidney cortex of rats. Pattyn, V.M., Verpooten, G.A., Giuliano, R.A., Zheng, F., De Broe, M.E. J. Pharmacol. Exp. Ther. (1988) [Pubmed]
  11. Pertussis toxin differentiates between alpha 1- and alpha 2-adrenoceptor-mediated inhibition of noradrenaline release from rat kidney cortex. Murphy, T.V., Majewski, H. Eur. J. Pharmacol. (1990) [Pubmed]
  12. Endogenous regucalcin suppresses the enhancement of protein phosphatase activity in the cytosol and nucleus of kidney cortex in calcium-administered rats. Morooka, Y., Yamaguchi, M. J. Cell. Biochem. (2002) [Pubmed]
  13. Gene profiling the effects of calcium deficiency versus 1,25-dihydroxyvitamin D induced hypercalcemia in rat kidney cortex. Bajwa, A., Horst, R.L., Beckman, M.J. Arch. Biochem. Biophys. (2005) [Pubmed]
  14. Antitumor effects due to irreversible stoppage of tumor tissue blood flow: evaluation of a novel combretastatin A-4 derivative, AC7700. Hori, K., Saito, S., Nihei, Y., Suzuki, M., Sato, Y. Jpn. J. Cancer Res. (1999) [Pubmed]
  15. Expression cloning of a cDNA from rabbit kidney cortex that induces a single transport system for cystine and dibasic and neutral amino acids. Bertran, J., Werner, A., Moore, M.L., Stange, G., Markovich, D., Biber, J., Testar, X., Zorzano, A., Palacin, M., Murer, H. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  16. Megalin-mediated endocytosis of transcobalamin-vitamin-B12 complexes suggests a role of the receptor in vitamin-B12 homeostasis. Moestrup, S.K., Birn, H., Fischer, P.B., Petersen, C.M., Verroust, P.J., Sim, R.B., Christensen, E.I., Nexø, E. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  17. Phosphorylation and activation of protamine kinase by two forms of a myelin basic protein kinase from extracts of bovine kidney cortex. Reddy, S.A., Guo, H., Tarun, S.Z., Damuni, Z. J. Biol. Chem. (1993) [Pubmed]
  18. Photoaffinity labeling of the epithelial sodium channel. Kleyman, T.R., Yulo, T., Ashbaugh, C., Landry, D., Cragoe, E., Karlin, A., Al-Awqati, Q. J. Biol. Chem. (1986) [Pubmed]
  19. The regulation of phosphoenolpyruvate carboxykinase (GTP) synthesis in rat kidney cortex. The role of acid-base balance and glucocorticoids. Iynedjian, P.B., Ballard, F.J., Hanson, R.W. J. Biol. Chem. (1975) [Pubmed]
  20. Distribution of anticancer agents in spontaneous animal tumors. II. Distribution of gallium in canine lymphosarcoma. Straw, J.A., Klubes, P., Hart, M.M. J. Natl. Cancer Inst. (1975) [Pubmed]
  21. Expression cloning and functional characterization of the kidney cortex high-affinity proton-coupled peptide transporter. Boll, M., Herget, M., Wagener, M., Weber, W.M., Markovich, D., Biber, J., Clauss, W., Murer, H., Daniel, H. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  22. Surface densities of diaphragmed fenestrae and transendothelial channels in different murine capillary beds. Milici, A.J., L'Hernault, N., Palade, G.E. Circ. Res. (1985) [Pubmed]
  23. Regulation of citrate transport and pyruvate dehydrogenase in rat kidney cortex mitochondria by bicarbonate. Robinson, B.H., Oei, J., Cheema-Dhadli, S., Halperin, M.L. J. Biol. Chem. (1977) [Pubmed]
  24. Purification and properties of a distinct protamine kinase from the cytosol of bovine kidney cortex. Damuni, Z., Amick, G.D., Sneed, T.R. J. Biol. Chem. (1989) [Pubmed]
  25. Na/H antiporter mRNA expression in single nephron segments of rat kidney cortex. Krapf, R., Solioz, M. J. Clin. Invest. (1991) [Pubmed]
  26. Parathyroid hormone acutely increases polyphosphoinositides of the rabbit kidney cortex by a cycloheximide-sensitive process. Farese, R.V., Bidot-López, P., Sabir, A., Smith, J.S., Schinbeckler, B., Larson, R. J. Clin. Invest. (1980) [Pubmed]
  27. Localization of the membrane defect in transepithelial transport of taurine by parallel studies in vivo and in vitro in hypertaurinuric mice. Chesney, R.W., Scriver, C.R., Mohyuddin, F. J. Clin. Invest. (1976) [Pubmed]
  28. The purine nucleotide cycle. A pathway for ammonia production in the rat kidney. Bogusky, R.T., Lowenstein, L.M., Lowenstein, J.M. J. Clin. Invest. (1976) [Pubmed]
  29. Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney. Gorin, Y., Block, K., Hernandez, J., Bhandari, B., Wagner, B., Barnes, J.L., Abboud, H.E. J. Biol. Chem. (2005) [Pubmed]
  30. Identification of endothelin receptor subtypes in rat kidney cortex using subtype-selective ligands. Nambi, P., Wu, H.L., Pullen, M., Aiyar, N., Bryan, H., Elliott, J. Mol. Pharmacol. (1992) [Pubmed]
  31. Furosemide stimulates macula densa cyclooxygenase-2 expression in rats. Mann, B., Hartner, A., Jensen, B.L., Kammerl, M., Krämer, B.K., Kurtz, A. Kidney Int. (2001) [Pubmed]
  32. Cyclin E and p27 protein content in human renal cell carcinoma: clinical outcome and associations with cyclin D. Hedberg, Y., Davoodi, E., Ljungberg, B., Roos, G., Landberg, G. Int. J. Cancer (2002) [Pubmed]
  33. Relaxin-1-deficient mice develop an age-related progression of renal fibrosis. Samuel, C.S., Zhao, C., Bond, C.P., Hewitson, T.D., Amento, E.P., Summers, R.J. Kidney Int. (2004) [Pubmed]
  34. L-pipecolic acid oxidation in the rabbit and cynomolgus monkey. Evidence for differing organellar locations and cofactor requirements in each species. Mihalik, S.J., Rhead, W.J. J. Biol. Chem. (1989) [Pubmed]
  35. The apical Cl/HCO3 exchanger of beta intercalated cells. van Adelsberg, J.S., Edwards, J.C., al-Awqati, Q. J. Biol. Chem. (1993) [Pubmed]
  36. Purification of a novel calcium-independent phospholipase A2 from rabbit kidney. Portilla, D., Dai, G. J. Biol. Chem. (1996) [Pubmed]
  37. Further studies on acetamidination as a technique for preparation of a biologically valid 3-H-labeled tracer for parathyroid hormone. Zull, J.E., Chuang, J. J. Biol. Chem. (1975) [Pubmed]
  38. Vasodilatory N-methyl-D-aspartate receptors are constitutively expressed in rat kidney. Deng, A., Valdivielso, J.M., Munger, K.A., Blantz, R.C., Thomson, S.C. J. Am. Soc. Nephrol. (2002) [Pubmed]
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