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Gene Review

Aloxe3  -  arachidonate lipoxygenase 3

Mus musculus

Synonyms: Epidermal LOX-3, Epidermis-type lipoxygenase 3, Hydroperoxide isomerase ALOXE3, Hydroperoxy icosatetraenoate dehydratase, e-LOX-3, ...
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High impact information on Aloxe3

  • The mouse Hes7 gene is located next to Aloxe3, which is mapped to a position 37.0 cM from the centromere on chromosome 11 [1].
  • Degenerative-nested PCR analyses using primers encoded by highly conserved sequences in lipoxygenases detected 5-lipoxygenase, leukocyte-type 12-lipoxygenase, platelet-type 12-lipoxygenase, 8-lipoxygenase, and epidermis-type lipoxygenase-3 in mouse intestinal tissue [2].

Analytical, diagnostic and therapeutic context of Aloxe3


  1. Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm. Bessho, Y., Miyoshi, G., Sakata, R., Kageyama, R. Genes Cells (2001) [Pubmed]
  2. Arachidonic and linoleic acid metabolism in mouse intestinal tissue: evidence for novel lipoxygenase activity. Kawajiri, H., Hsi, L.C., Kamitani, H., Ikawa, H., Geller, M., Ward, T., Eling, T.E., Glasgow, W.C. Arch. Biochem. Biophys. (2002) [Pubmed]
  3. cDNA cloning, genomic structure, and chromosomal localization of a novel murine epidermis-type lipoxygenase. Kinzig, A., Heidt, M., Fürstenberger, G., Marks, F., Krieg, P. Genomics (1999) [Pubmed]
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